ASSESSMENT OF HEMATOLOGICAL AND MORPHOLOGICAL INDICES IN EXPERIMENTAL ANIMALS WHILE IMPLANTATING CARBON COMPOSITION FIBER

Aim. To study in experiment the response of biological tissues and systems of experimental animals to implantation of carbon composition fiber. Material and methods. During the experiment, two groups of outbred white rats (males) were used: group 1 included 25 animals, who were intramuscularly implanted “pure” carbon fiber (CF); group 2-25 animals with intramuscularly introduced finished CF. the control group consisted of 20 animals kept in the same conditions as experimental groups, but without implantation of any materials. To determine the cell composition of peripheral blood, the samples were taken from the caudal vein. Phagocytic activity of peripheral blood leukocytes was studied with V.N. Kaplin method using formalinized sheep erythrocytes. Results. It was detected that when using carbon materials there is observed activation of monocytic-macrophage and lymphocytic links of immune system during the first 7 days that later contributes to formation of reparative process. Conclusions. The experimental data confirmed the biological compatibility of carbon fiber that permits to use it in practical dentistry.

Biological compatibile materials, carbon fiber, immunological reaction, histological study, monocytic-macrophage link, reparative process