CORRELATION BETWEEN MICRO- AND MACRO-STRUCTURAL CEREBRAL MAGNETORESONANCE INDICES AND CLINICAL-FUNCTIONAL STATUS OF PATIENTS WITH ACUTE ISCHEMIC STROKE


Cite item

Full Text

Abstract

Aim. To assess the correlation between micro and macrostructural cerebral magnetoresonance indices and clinical-functional status of patients with ischemic stroke in its acute period. Materials and methods. One hundred and three patients in the acute period of ischemic stroke underwent complex MRT study of the brain with assessment of morphometric indices and fractional anisotropy (FA) of 10 zones including 5 tracts of white substance. The obtained data were analyzed in context of correlation with neurological, cognitive and functional status of patients. Results. Differences in fractional anisotropy on the side of acute ischemic stroke and in the opposite hemisphere were revealed. The focus size is connected with the severity of neurological deficit, cognitive and functional status, but not with the status of tracts. Leucoareosis area and ventricular system volume are associated with neurological, cognitive and functional status as well as with the microstructure of thalamus, hippocampus, anterior limb of internal capsule, cingulate fascicle, frontooccipital fascicle and corpus callosum. The volume of hippocampus is associated only with FA of cingulate fascicle, but not with clinical data. Conclusions. The obtained data can testify adaptive mechanisms, which can start realizing at the microstructural level already in the acute period of ischemic stroke. Chronic vascular cerebral injury is the most significant factor influencing microstructure of gray and white substance of the brain along with the focal size determining neurological, cognitive and functional status in acute stroke patients.

About the authors

A A Kulesh

Пермский государственный медицинский университет им. академика Е. А. Вагнера

Email: aleksey.kulesh@gmail.com
кандидат медицинских наук, доцент кафедры неврологии с курсом нейрореабилитологии ДПО

V E Drobakha

Городская детская клиническая больница № 15

врач-рентгенолог

V V Shestakov

Пермский государственный медицинский университет им. академика Е. А. Вагнера

доктор медицинских наук, профессор, заведующий кафедрой неврологии с курсом нейрореабилитологии ДПО

References

  1. Дробаха В. Е., Кулеш А. А., Шестаков В. В. Диагностические возможности диффузионно-тензорной магнитно-резонансной томографии в остром периоде ишемического инсульта. Врач-аспирант 2015; 2: 69: 77-83.
  2. Кулеш А. А., Дробаха В. Е., Шестаков В. В. Магнитно-резонансная морфометрия головного мозга у пациентов с постинсультными когнитивными нарушениями. Пермский медицинский журнал 2014; 31 (3): 39-45.
  3. Beaulieu C., Johansen-Berg H., Behrens T. Diffusion MRI: from quantitative measurement to in vivo neuroanatomy. London: Elsevier, 2009; 490.
  4. Chen J. L., Schlaug G. Resting state interhemispheric motor connectivity and white matter integrity correlate with motor impairment in chronic stroke. Frontiers in neurology 2013; 4: 1-7.
  5. Fernández-Andújar M., Doornink F., Dacosta-Aguayo R. Remote thalamic microstructural abnormalities related to cognitive function in ischemic stroke patients. Neuropsychology 2014; 28 (6): 984-996.
  6. Guo J., Wang S., Li R. Cognitive impairment and whole brain diffusion in patients with carotid artery disease and ipsilateral transient ischemic attack. Neurol. Res. 2014; 36 (1): 41-46.
  7. Li Y., Wu P., Liang F., Huang W. The microstructural status of the corpus callosum is associated with the degree of motor function and neurological deficit in stroke patients. PLoS ONE 2015; 104: e0122615.
  8. Lindenberg R., Renga V., Zhu L. L. Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke. Neurology 2010; 74: 280-287.
  9. MacIntosh B. J., Graham S. J. Magnetic resonance imaging to visualize stroke and characterize stroke recovery: a review. Front. Neurol. 2013; 4: 60.
  10. Rong D., Zhang M., Ma Q. Corticospinal tract change during motor recovery in patients with medulla infarct: a diffusion tensor imaging study. BioMed Research International 2014, available at: http://dx.doi.org/ 10.1155/2014/524096.
  11. Schaechter J. D., Fricker Z. P., Perdue K. L. Microstructural status of ipsilesional and contralesional corticospinal tract correlates with motor skill in chronic stroke patients. Hum. Brain. Mapp. 2009; 30: 3461-3474.
  12. Song J., Nair V. A., Young B. M., Walton L. M., Nigogosyan Z., Remsik A., Tyler M. E., Farrar-Edwards D., Caldera K. E., Sattin J. A., Williams J. C., Prabhakaran V. DTI measures track and predict motor function outcomes in stroke rehabilitation utilizing BCI technology. Front Hum. Neurosci. 2015; 9: 195.
  13. Stinear C. M., Barber P. A., Smale P. R. Functional potential in chronic stroke patients depends on corticospinal tractintegrity. Brain 2007; 130(Pt 1): 170-180.
  14. Takenobu Y., Hayashi T., Moriwaki H., Nagatsuka K., Naritomi H., Fukuyama H. Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke. NeuroImage 2014; Clinical 4: 201-208.
  15. Yu C., Zhu C., Zhang Y. A longitudinal diffusion tensor imaging study on wallerian degeneration of corticospinal tract after motor pathways stroke. Neuroimage 2009; 47: 451-458.

Copyright (c) 2015 Kulesh A.A., Drobakha V.E., Shestakov V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies