PECULIARITIES OF EARLY PROCESS COURSE IN RATS AGAINST THE BACKGROUND OF ALLOXAN DIABETES WHEN USING DIFFERENT METHODS OF LOCAL THERAPY

Aim. The aim of the study was to determine the clinical efficiency of local use of “Miliacyl” and EHF-therapy for the treatment of purulent wounds against the background of alloxan diabetes in experimental conditions. Materials and methods. One hundred and forty white outbred rats were studied. In the main group, miliacyl and EHF-therapy were used for the treatment of purulent wounds. In the control group I no therapy of wounds was carried out; in the control group II “Miliacyl” was used; EHF-therapy was applied in 24 rats of the control group III. Results. In experimental animals, damage of pancreatic islet cells during the early period of observation was reflected in different types of structural changes, predominantly of the degenerative type. Comparative study of tissue structures of purulent wounds in different conditions showed a high therapeutic efficiency of combined use of “Miliacyl” and EHF-therapy. Strengthening of leukocytic and macrophagal reactions, faster arrest of inflammatory process and separation of necrotic masses was revealed. Conclusions. Potentiation phenomenon of anti-inflammatory and regenerator effect when using miliacyl and EHF was stated.

“Miliacyl”, EHF-therapy, alloxan diabetes, wounds