COVID-19 immune trace: predictors of rheumatoid arthritis development

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Abstract

Objective. To assess the effect of coronavirus infection on the development of true arthritis in patients with post-COVID joint syndrome

Materials and methods. Factors contributing to the development of true rheumatic disease in patients with confirmed coronavirus infection were evaluated in a prospective cohort study. General clinical and immunological tests, including markers of rheumatoid arthritis were determined.

Results. On the basis of the results of this study, it was found out that COVID-19 may act as a trigger for autoimmune diseases.

Conclusions. The results of the study indicate the trigger role of COVID-19 in the development of autoimmune diseases. Preventive measures aimed at early detection of rheumatoid arthritis among patients with SARS-COV2 are control of leukocyte count and rheumatoid arthritis markers. A follow-up with a rheumatologist with a periodic monitoring of clinical and immunological parameters is recommended if joint syndrome is revealed.

About the authors

A. K. Karibova

City Clinical Hospital

Author for correspondence.
Email: solomon687@gmail.com
ORCID iD: 0009-0003-3690-3041

Head of the Department of Rheumatology

Russian Federation, Makhachkala

O. V. Khlynova

Ye.A. Vagner Perm State Medical University

Email: solomon687@gmail.com
ORCID iD: 0000-0003-4860-0112

DSc (Medicine), Professor, Head of the Department of Hospital Therapy and Cardiology

Russian Federation, Perm

M. T. Kudaev

Dagestan State Medical University

Email: solomon687@gmail.com
ORCID iD: 0000-0001-5446-1775

DSc (Medicine), Professor, Head of the Department of Therapy

Russian Federation, Makhachkala

S. Sh. Akhmedkhanov

Dagestan State Medical University

Email: solomon687@gmail.com
ORCID iD: 0000-0002-8935-220X

DSc (Medicine), Professor, Head of the Department of Internal Diseases of the Pediatric and Dental Faculties

Russian Federation, Makhachkala

D. I. Mustafaev

Dagestan State Medical University

Email: solomon687@gmail.com
ORCID iD: 0009-0004-6333-3790

Resident

Russian Federation, Makhachkala

References

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Supplementary files

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2. Fig. 1. Dependence of RA: a – on the level of Lc; b – on the level of ESR; c – on the level of D-dimer

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3. Fig. 2. Association of RA with articular syndrome in the post-COVID period

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