Influence of vaccine prevention on the spread and serotype composition of Streptococcus pneumoniae in military collectives
- Authors: Mukhachev I.S.1, Blagonravova A.S.2, Feldblyum I.V.2, Alyeva M.K.2
-
Affiliations:
- 1026 Center of State Sanitary and Epidemiological Surveillance
- E.A. Wagner Perm State Medical University
- Issue: Vol 41, No 1 (2024)
- Pages: 141-147
- Section: Preventive and social medicine
- URL: https://journals.rcsi.science/PMJ/article/view/254853
- DOI: https://doi.org/10.17816/pmj411141-147
- ID: 254853
Cite item
Abstract
Materials and methods. The study was conducted among 369 military personnel of the military unit of the Sverdlovsk region. Determination of the frequency and serotype of S. pneumoniae was carried out upon admission and after 1.5 months of stay in the military collective using the multiplex PCR method.
Results. After 1.5 months of stay of servicemen in the military collective, a significant activation of pneumococcal circulation was established (χ2McNemar=24.038; p<0.001). The risk of S. pneumoniae infection among unvaccinated military personnel was 1.39 times higher compared to vaccinated military personnel (RR=1.39; 95% CI 1.209–1.596). In the group of unvaccinated military personnel, the frequency of occurrence of vaccine serotypes was 2.6 times higher than in vaccinated ones (χ2 = 6.25; p = 0.01).
Conclusions. The proactive influence of immunization against pneumococcal infection on the prevalence and serotype landscape of S. pneumoniae has been established: A low prevalence of vaccine serotypes and a predominance of non-typeable serotypes have been revealed among vaccinated individuals.
Full Text
##article.viewOnOriginalSite##About the authors
Ivan S. Mukhachev
1026 Center of State Sanitary and Epidemiological Surveillance
Author for correspondence.
Email: faust.78@mail.ru
ORCID iD: 0000-0003-2669-7144
SPIN-code: 6098-5137
Head, Chief State Health Officer of Central Military District
Russian Federation, YekaterinburgAnna S. Blagonravova
E.A. Wagner Perm State Medical University
Email: a.blagonravova@mail.ru
ORCID iD: 0000-0002-1467-049X
SPIN-code: 9578-5044
MD, PhD, Acting Rector
Russian Federation, PermIrina V. Feldblyum
E.A. Wagner Perm State Medical University
Email: irinablum@mail.ru
ORCID iD: 0000-0003-4398-5703
SPIN-code: 3394-9879
MD, PhD, Professor, the Head of the Department of Epidemiology
Russian Federation, PermMaya Kh. Alyeva
E.A. Wagner Perm State Medical University
Email: alyeva.mx@mail.ru
ORCID iD: 0000-0002-4467-4707
SPIN-code: 3211-3245
Candidate of Medical Sciences, Associate Professor of the Department of Epidemiology
Russian Federation, PermReferences
- Куликов П.В., Жоголев С.Д., Жоголев К.Д., Аминев Р.М. Эпидемиологическая и этиологическая характеристика внебольничных пневмоний на современном этапе. Известия Российской Военно-медицинской академии 2018; 37 (3): 14–23. / Kulikov P.V., Zhogolev S.D., Zhogolev K.D., Aminev R.M. Epidemiological and etiological characteristics of community-acquired pneumonia at the present stage. Bulletin of the Russian Military Medical Academy 2018; 37 (3): 14–23 (in Russian).
- Диагностика, лечение и вакцинопрофилактика внебольничной пневмонии у военнослужащих. Методические указания. М.: МО РФ ГВМУ 2015; 58. / Diagnosis, treatment and vaccine prevention of community-acquired pneumonia in military personnel. Methodical instructions. Mocsow: Ministry of Defense of the Russian Federation GVMU 2015; 58 (in Russian).
- Зайцев А.А. Эпидемиология заболеваний органов дыхания у военнослужащих и направления совершенствования пульмонологической помощи. Военно-медицинский журнал 2018; 339 (11): 4–9. / Zaitsev A.A. Epidemiology of respiratory diseases in military personnel and directions for improving pulmonary care. Military Medical Journal 2018; 339 (11): 4–9 (in Russian).
- Лучанинов Э.В., Туркутюков В.Б., Колосов В.П. Эпидемиологические особенности заболеваемости внебольничной пневмонией у военнослужащих. Бюллетень физиологии и патологии дыхания 2007; (25): 87–88. / Luchaninov E.V., Turkutyukov V.B., Kolosov V.P. Epidemiological features of the incidence of community-acquired pneumonia in military personnel. Bulletin of Physiology and Pathology of Respiration 2007; (25): 87–88 (in Russian).
- Heo J.Y., Lee J.E., Kim H.K., Choe K.W. Acute lower respiratory tract infections in soldiers, South Korea, April 2011 – March 2012. Emerg Infect Dis. 2014; 20 (5): 875–877. doi: 10.3201/eid2005.131692.
- Обзор Главного государственного санитарного врача Министерства обороны Российской Федерации о заболеваемости военнослужащих и деятельности центров государственного санитарно-эпидемиологического надзора Министерства обороны Российской Федерации за 2022 год. М.: МО РФ ГВМУ 2023; 14–15. / Review of the Chief State Sanitary Doctor of the Ministry of Defense of the Russian Federation on the incidence of sickness in military personnel and the activities of the centers of state sanitary and epidemiological surveillance of the Ministry of Defense of the Russian Federation for 2019. Moscow: Ministry of Defense of the Russian Federation GVMU 2023; 14–15 (in Russian).
- Денисова А.Р., Максимов М.Л. Острые респираторные вирусные инфекции: этиология, диагностика, современный взгляд на лечение. РМЖ. Медицинское обозрение 2018; 1 (II): 99–103. / Denisova A.R., Maksimov M.L. Acute respiratory viral infections: etiology, diagnosis, modern view of treatment. RMJ. Medical Review 2018; 1 (II): 99–103 (in Russian).
- Gentile G., Fréchard G., Dia A. et al. Incidence of acute respiratory tract infections (2006–2015) and influenza (2006–2013) among French armed forces. Med Mal Infect. 2020; 50 (8): 689–695. doi: 10.1016/j.medmal.2019.10.015.
- Общая эпидемиология с основами доказательной медицины: руководство к практическим занятиям: учебное пособие. Под ред. В.И. Покровский, Н.И. Брико. 2-е изд., испр. и доп. М.: ГЭОТАР-Медиа 2018; 192–194. /General epidemiology with the basics of evidence-based medicine: a guide to practical training: a textbook. Edited by V.I. Pokrovsky, N.I. Briko. 2nd ed., rev. and additional. Mocsow: GEOTAR-Media 2018; 192–194 (in Russian).
