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Post a Comment Influence of vaccine prevention on the spread and serotype composition of Streptococcus pneumoniae in military collectives
- Authors: Mukhachev I.S.1, Blagonravova A.S.2, Feldblyum I.V.2, Alyeva M.K.2
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Affiliations:
- 1026 Center of State Sanitary and Epidemiological Surveillance
- E.A. Wagner Perm State Medical University
- Issue: Vol 41, No 1 (2024)
- Pages: 141-147
- Section: Preventive and social medicine
- URL: https://journals.rcsi.science/PMJ/article/view/254853
- DOI: https://doi.org/10.17816/pmj411141-147
- ID: 254853
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Abstract
Objective. Study of the effect of vaccination against pneumococcal infection on the prevalence and serotype composition of S. pneumoniae in military personnel.
Materials and methods. The study was conducted among 369 military personnel of the military unit of the Sverdlovsk region. Determination of the frequency and serotype of S. pneumoniae was carried out upon admission and after 1.5 months of stay in the military collective using the multiplex PCR method.
Results. After 1.5 months of stay of servicemen in the military collective, a significant activation of pneumococcal circulation was established (χ2McNemar=24.038; p<0.001). The risk of S. pneumoniae infection among unvaccinated military personnel was 1.39 times higher compared to vaccinated military personnel (RR=1.39; 95% CI 1.209–1.596). In the group of unvaccinated military personnel, the frequency of occurrence of vaccine serotypes was 2.6 times higher than in vaccinated ones (χ2 = 6.25; p = 0.01).
Conclusions. The proactive influence of immunization against pneumococcal infection on the prevalence and serotype landscape of S. pneumoniae has been established: A low prevalence of vaccine serotypes and a predominance of non-typeable serotypes have been revealed among vaccinated individuals.
Materials and methods. The study was conducted among 369 military personnel of the military unit of the Sverdlovsk region. Determination of the frequency and serotype of S. pneumoniae was carried out upon admission and after 1.5 months of stay in the military collective using the multiplex PCR method.
Results. After 1.5 months of stay of servicemen in the military collective, a significant activation of pneumococcal circulation was established (χ2McNemar=24.038; p<0.001). The risk of S. pneumoniae infection among unvaccinated military personnel was 1.39 times higher compared to vaccinated military personnel (RR=1.39; 95% CI 1.209–1.596). In the group of unvaccinated military personnel, the frequency of occurrence of vaccine serotypes was 2.6 times higher than in vaccinated ones (χ2 = 6.25; p = 0.01).
Conclusions. The proactive influence of immunization against pneumococcal infection on the prevalence and serotype landscape of S. pneumoniae has been established: A low prevalence of vaccine serotypes and a predominance of non-typeable serotypes have been revealed among vaccinated individuals.
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##article.viewOnOriginalSite##About the authors
Ivan S. Mukhachev
1026 Center of State Sanitary and Epidemiological Surveillance
Author for correspondence.
Email: faust.78@mail.ru
ORCID iD: 0000-0003-2669-7144
SPIN-code: 6098-5137
Head, Chief State Health Officer of Central Military District
Russian Federation, YekaterinburgAnna S. Blagonravova
E.A. Wagner Perm State Medical University
Email: a.blagonravova@mail.ru
ORCID iD: 0000-0002-1467-049X
SPIN-code: 9578-5044
MD, PhD, Acting Rector
Russian Federation, PermIrina V. Feldblyum
E.A. Wagner Perm State Medical University
Email: irinablum@mail.ru
ORCID iD: 0000-0003-4398-5703
SPIN-code: 3394-9879
MD, PhD, Professor, the Head of the Department of Epidemiology
Russian Federation, PermMaya Kh. Alyeva
E.A. Wagner Perm State Medical University
Email: alyeva.mx@mail.ru
ORCID iD: 0000-0002-4467-4707
SPIN-code: 3211-3245
Candidate of Medical Sciences, Associate Professor of the Department of Epidemiology
Russian Federation, PermReferences
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