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Post a Comment Epidemiological characteristics of hepatitis c infection in Nizhny Novgorod at the first stage of infection control program (2016–2021)
- Authors: Kashnikova A.D.1, Polyanina A.V.1, Zaitseva N.N.1, Bystrova T.N.1
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Affiliations:
- Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
- Issue: Vol 40, No 5 (2023)
- Pages: 100-109
- Section: Preventive and social medicine
- URL: https://journals.rcsi.science/PMJ/article/view/254811
- DOI: https://doi.org/10.17816/pmj405100-109
- ID: 254811
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Abstract
Objective. To characterize the peculiarities of the epidemic process of viral hepatitis C in Nizhny Novgorod at the first stage of the infection control program (2016–2021).
Materials and Methods. A retrospective analysis of the incidence of registered forms of HCV infection in Nizhny Novgorod was carried out using information of statistical and analytical materials. A total of 78 883 blood serum samples were collected from individuals undergoing pre-hospital screening and admitted to non-infectious hospitals from 2016 to 2021. Laboratory testing included the determination of HCV infection markers: anti-HCV IgM and IgG, antibodies to structural and non-structural proteins (n = 2953). Seropositive samples were tested for the presence of HCV RNA (n = 467) using the Real Time PCR method.
Results. A trend towards a decrease in the incidence of registered forms of HCV infection was observed in Nizhny Novgorod from 2016 to 2021. It was found that among the various suspected transmission routes and risk factors for HCV infection, the predominant ones were a history of injected drug used and sexual transmission. The seroprevalence of anti-HCV was 3.6 ± 0.1 % and the prevalence of HCV RNA among the adult population was 1.8 ± 0.1 %. The highest prevalence of active HCV infection was observed in the age groups of 30–39 years (3.3 ± 0.3 %) and 40–49 years (5.7 ± 0.5 %).
Conclusions. To achieve the goals of the HCV elimination program, targeted and dynamic seroepidemiological studies are necessary to increase the number of individuals screened for HCV infection markers, with subsequent expansion of access to effective antiviral therapy for those with active infection.
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##article.viewOnOriginalSite##About the authors
A. D. Kashnikova
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Author for correspondence.
Email: gabckad@gmail.com
ORCID iD: 0000-0001-9893-5848
SPIN-code: 6002-8194
researcher, Laboratory of Epidemiology and Viral Hepatites
Russian Federation, Nizhny NovgorodA. V. Polyanina
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Email: polyanina.anastasia@yandex.ru
ORCID iD: 0000-0003-1258-5467
SPIN-code: 8245-4909
Scopus Author ID: 57194604102
Candidate of Medical Sciences, Leading Researcher, Head of the Laboratory of Epidemiology and Viral Hepatites
Russian Federation, Nizhny NovgorodN. N. Zaitseva
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Email: micro@nniiem.ru
ORCID iD: 0000-0001-5370-4026
Scopus Author ID: 7101903242
MD, PhD, Director
Russian Federation, Nizhny NovgorodT. N. Bystrova
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Email: gepatit-bystrova@yandex.ru
ORCID iD: 0000-0002-2719-6328
Scopus Author ID: 57225802197
MD, PhD, Professor, Leading Researcher, Laboratory of Epidemiology and Viral Hepatites
Russian Federation, Nizhny NovgorodReferences
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