Caroli's disease with multiple cholangiogenic abscesses of left liver lobe: a clinical case

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Abstract

To analyze the methods of diagnostics, treatment and outcomes of Caroli disease. The medical history, diagnostic methods and treatment of a patient with a clinical diagnosis of Caroli's disease were studied on the basis of the Surgical Department of the First Republican Clinical Hospital in Izhevsk. The results of the study showed that the final clinical diagnosis was made on the basis of the following: complaints, disease development, instrumental and laboratory diagnostic data. A timely surgical intervention, combined with all diagnostic methods, identified a rare and difficult clinical diagnosis – Caroli’s disease. In the presented clinical case, after collecting anamnesis and conducting studies, a diagnosis of a rare Caroli’s disease was made and a planned operation was performed. A regular monitoring of X-ray examinations, biochemical blood tests, and a timely medical care provide a favorable prognosis – long-term remission. In case of complications, there is a high risk for the development of biliary cirrhosis.

About the authors

S. N. Styazhkina

Izhevsk State Medical Academy; First Republican Clinical Hospital

Author for correspondence.
Email: sstazkina064@gmail.com

MD, PhD, Professor, Department of Faculty Surgery

Russian Federation, Izhevsk; Izhevsk

D. V. Zaitsev

First Republican Clinical Hospital

Email: sstazkina064@gmail.com

Candidate of Medical Sciences, Head of the Department, surgeon of the highest qualification category

Russian Federation, Izhevsk

M. N. Klimentov

Izhevsk State Medical Academy; First Republican Clinical Hospital

Email: sstazkina064@gmail.com

Candidate of Medical Sciences, Associate Professor, Department of Faculty Surgery

Russian Federation, Izhevsk; Izhevsk

V. V. Larin

First Republican Clinical Hospital

Email: sstazkina064@gmail.com

Candidate of Medical Sciences, surgeon of the highest qualification category

Russian Federation, Izhevsk

M. А. Gasanova

Izhevsk State Medical Academy

Email: sstazkina064@gmail.com

fifth-year student

Russian Federation, Izhevsk

M. I. Chakmina

Izhevsk State Medical Academy

Email: sstazkina064@gmail.com

fifth-year student, Faculty of Medicine

Russian Federation, Izhevsk

References

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  2. Taylor A.C., Palmer K.R. Caroli`s disease. Eur. J. Gastroenterol. 1998; 10 (2): 105–108.
  3. Miller W.J., Sechtin A.G., Campbell W.L., Pieters P.C. Imaging findings in Caroli’s disease. AJR Am J Roentgenol 1995; 165: 333–7.
  4. Ros E., Navarro S., Bru C., Gilabert R., Bianchi L., Bruguera M. Ursodeoxy cholic acid treatment of primary hepatolithiasis in Caroli’s syndrome. Lancet 1993; 342: 404–6.
  5. Klimentov M.N., Styazhkina S.N., Medvedeva O.V., Pestereva V.A., Dzyuin M.S. Clinical case of a combination of cholelithiasis, obstructive jaundice and portal “staghorn” cholangiolithiasis: on the issue of terminology, available at: https://cyberleninka.ru/article/n/klinicheskiy-sluchay-sochetaniya-zhelchnokamennoy-bolezni-mehanicheskoy-zheltuhi-i-vorotnogo-korallovidnogo-holangiolitiaza-k (in Russian).
  6. Sitnikov V.A., Styazhkina S.N., Ibragimova D.R., Kasimova N.R. Iatrogenesis as a cause of postcholecystectomy syndrome available at: https://cyberleninka.ru/article/n/yatrogeniya-kak-prichina-postholetsistektomicheskogo-sindroma (in Russian).
  7. Styazhkina S.N., Zaitsev D.V., Bagautdinov A.L., Sharafutdinov M.R., Antropova Z.A., Zaripov I.I., Kamalov M.I. The first TIPS operation performed in the Udmurt Republic, to save a young patient with secondary biliary cirrhosis. Acta Biomedica Scientifica 2023, available at: https://doi.org/10.29413/ABS.2023-8.2.23 (in Russian).
  8. Karelskaya N.A., Karmazanovsky G.G. Magnetic resonance cholangiopancreatography. Moscow: VIDAR-M, 2014; 272 (in Russian).

Supplementary files

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2. Fig. 1. Macroscopic specimen: the left lobe of the liver with cystic transformation of the ducts, fibrosis of the parenchyma

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3. Fig. 2. MRI cholangiopancreatography: Cystic transformed ducts of the left lobe with the presence of stones

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