Prognosis of forming phenotype of comorbidity of arterial hypertension and erosive-ulcerative le-sions of gastroduodenal zone in railway transport workers

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Abstract

Objective. To study the clinical and laboratory features of the formation of a combination of arterial hypertension in patients with erosive and ulcerative lesions of the gastroduodenal zone and to develop a method for predicting the probability of developing this phenotype. Arterial hypertension and diseases of the gastrointestinal tract are among the common diseases, which are often observed in the same patients.

Materials and methods. Employees (n = 127, males only) of locomotive crews, who work for more than 10 years at Perm-II Railway Station of Sverdlovsk Branch of OJSC Russian Railways, were examined. The methods of examination included the analysis of anamnesis data, physical, laboratory and instrumental examinations of patients. Laboratory studies included the analysis of the results of a general blood test, the serum concentration of common biochemical parameters (glucose and cholesterol), as well as the concentration of individual proteins: endothelin-1, monocyte chemotactic protein-1 and C-reactive protein.

Results. The diagnostic value of determining a number of indicators for predicting the development of arterial hypertension in patients with erosive and ulcerative manifestations of the gastrointestinal tract was established. The greatest significance for the diagnosis of comorbidity was demonstrated by the level of endothelin-1, glucose and cholesterol as well as the content of white blood cells and platelets. The data obtained made it possible to develop a mathematical formula for calculating the risk of arterial hypertension in patients with erosive and ulcerative lesions of the gastroduodenal system.

Conclusions. Employees of locomotive crews have an increased risk for comorbid pathology formation – arterial hypertension against the background of erosive and ulcerative lesions of the gastroduodenal zone, which is accompanied by a change in a number of laboratory parameters that can be used to predict the risk of developing comorbid pathology.

About the authors

N. N. Malyutina

E.A. Vagner Perm State Medical University

Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-3475-2505
SPIN-code: 9767-7035
Scopus Author ID: 5581639500

MD, PhD, Professor, Head of the Department of Faculty Therapy № 2, Occupational Diseases and Clinical Laboratory Diagnostics

Russian Federation, Perm

N. D. Yuy

E.A. Vagner Perm State Medical University; Clinical Hospital “RZhD – Meditsina”

Email: sosnin_dm@mail.ru

Candidate of Medical Sciences, Associate Professor, Department of Faculty Therapy № 2, Occupational Diseases and Clinical Laboratory Diagnostics

Russian Federation, Perm; Perm

S. V. Luzina

Clinical Hospital “RZhD – Meditsina”

Email: sosnin_dm@mail.ru
SPIN-code: 7400-5306

Candidate of Medical Sciences, Chief Physician

Russian Federation, Perm

D. M. Vatolin

E.A. Vagner Perm State Medical University

Email: sosnin_dm@mail.ru
SPIN-code: 9506-9216

Postgraduate Student, Department of Faculty Therapy № 2, Occupational Diseases and Clinical Laboratory Diagnostics

Russian Federation, Perm

D. Yu. Sosnin

E.A. Vagner Perm State Medical University

Author for correspondence.
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-1232-8826
SPIN-code: 4204-6796
Scopus Author ID: 36020670100

MD, PhD, Associate Professor, Professor, Department of Faculty Therapy № 2, Occupational Diseases and Clinical Laboratory Diagnostics

Russian Federation, Perm

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