Allergic bronchopulmonary aspergillosis (known unknown disease, analysis of clinical observation)

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Abstract

To show an algorithm for diagnosing this disease and demonstrate the effectiveness of etiological treatment using the case history of a patient with allergic bronchopulmonary aspergillosis (ABPA) against the background of bronchial asthma (BA).

Complaints, anamnesis, physical status, laboratory and instrumental studies of a patient with ABPA are published. Modern literature data on the diagnosis and treatment of ABPA have been analyzed.

The complaints, anamnesis, physical status as well as laboratory and instrumental studies used for a patient with ABPA were analyzed in comparison with world literature data.

Primary care physicians are informed insufficiently about the clinical picture of ABPA. Antimycotic therapy with variconazole applied for patients with ABPA against the background of BA leads not only to positive morphological changes in the lungs but also to the relief of BA course.

About the authors

O. P. Barlamov

Vesna Medical Group

Author for correspondence.
Email: barlamov@inbox.ru

Candidate of Medical Sciences, Chief Physician

Russian Federation, Perm

P. N. Barlamov

E.A. Vagner Perm State Medical University

Email: barlamov@inbox.ru
ORCID iD: 0000-0002-8704-692X

MD, PhD, Professor

Russian Federation, Perm

References

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  3. Kozlova Ya. I., Kuznetsov V.D., Klimko N.N. Fungi of the genus Aspergillus and chronic lung diseases. Doctor. 2020.11: 14–20. Agarwal R., Sehgal I.S., Dhooria S., Aggarwal A.N. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Review of Respiratory Medicine 2016; 10 (12): 1317–34 (in Russian).
  4. Agarwal R., Sehgal I.S., Dhooria S., Ag-garwal A.N. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Review of Respiratory Medicine 2016; 10 (12): 1317–34.
  5. Kanj A., Abdallah N., Soubani A.O. The spectrum of pulmonary aspergillosis. Respiratory Medicine 2018; 141: 121–31.
  6. Hinson K.F., Moon A.J., Plummer N.S. Bronchopulmonary aspergillosis; a review and a report of eight new cases. Thorax 1952; 7 (4): 317–33.
  7. Wark P., Hensley M., Saltos N. Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial. J Allergy Clin Immunol. 2003; 111 (5): 952–7. doi: 10.1067/mai.2003.1388.

Supplementary files

Supplementary Files
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2. Fig. 1. Patient B. Computed tomography of OGC dated 03.02.2022: the presented computed tomograms in lateral and transverse sections show that lateral sections of the S5-segment of the left lung are reduced in volume, airless, bronchi are deformed, small bronchiectasis

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3. Fig. 2. Patient B. Computed tomography of OGC dated June 15, 2022: a picture of bilateral bronchiolitis, atelectasis S5 of the right lung and subsegmental atelectasis S4 of the left lung. Few solid foci of both lungs, possibly eosinophilic infiltrates. Single enlarged right tracheobronchial nodule. When comparing with MSCT dated 03.02.2022 - appearance of atelectasis, bronchiolitis and enlargement of a single lymph node

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4. Fig. 3. Patient B. Computed tomography OGC dated September 22, 2022: resorption of atelectasis in S4-5 on the left and in the middle lobe on the right, bronchiectasis in S4-5 on the left

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