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Post a Comment Optimization of diagnostic approaches of destructive pancreatitis
- Authors: Zurnadzhyants V.A.1, Kchibekov E.A.1, Gasanov K.G.1, Bondarev V.A.1, Saydulaev W.A.1, Bondarev A.V.1
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Affiliations:
- Astrakhan State Medical University
- Issue: Vol 40, No 4 (2023)
- Pages: 82-91
- Section: Methods of diagnosis and technologies
- URL: https://journals.rcsi.science/PMJ/article/view/144150
- DOI: https://doi.org/10.17816/pmj40482-91
- ID: 144150
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Abstract
Objective. To improve the diagnostics of destructive pancreatitis based on the concentrations of fibrinogen degradation products and lysozyme in blood serum and peritoneal exudate.
Materials and methods. One hundred and two patients with acute pancreatitis were examined and the diagnostic significance of fibrinogen and lysozyme degradation products was assessed. The age of the patients ranged from 19 to 63 years. The patients were treated in surgical hospitals of the city of Astrakhan. Of them, 74 patients diagnosed an edematous form of acute pancreatitis, received conservative treatment, and 28 patients with destructive forms of pancreatitis were operated on. The reference values of the studied markers were evaluated in 39 healthy individuals (donors).
Results. In the blood serum of patients with destructive pancreatitis, the concentration of fibrinogen degradation products was 2.0 [0.68;13.2] mg/l, that is significantly higher than in the group of patients with edematous acute pancreatitis, as well as in the control group. After the surgery, in the peritoneal exudate of 28 operated patients with destructive pancreatitis, the concentrations of fibrinogen degradation products increased by 0.93 times compared to the group with edematous acute pancreatitis and by 3.1 times significantly higher than in the control group. There were no statistically significant differences in the concentrations of fibrinogen degradation products in the peritoneal exudate and in the blood serum of patients with destructive pancreatitis. The concentration of lysozyme in the blood serum of patients with destructive pancreatitis was 20 [5.0;46.5] mg/l, that is significantly higher than in the control group and in the edematous form of acute pancreatitis. After the surgery, the concentration of lysozyme in the peritoneal exudate was 2.5 times significantly higher in patients with destructive pancreatitis than in the control group. The average lysozyme concentration in the peritoneal exudate of patients with destructive pancreatitis exceeded the serum concentrations by 2.1 times in comparative equivalent.
Conclusions. Assessment of the levels of fibrinogen degradation products, lysozyme in the blood and exudate allows to diagnose the destruction of the pancreas, as well as to determine the correct treatment tactics.
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##article.viewOnOriginalSite##About the authors
Victor A. Zurnadzhyants
Astrakhan State Medical University
Email: zurviktor@yandex.ru
MD, PhD, Professor, Head of the Department of Surgical Diseases of the Pediatric Faculty
Russian Federation, AstrakhanEldar A. Kchibekov
Astrakhan State Medical University
Email: Eidar_76@inbox.ru
MD, PhD, Professor, Department of Surgical Diseases, Pediatric Faculty
Russian Federation, AstrakhanKazim G. Gasanov
Astrakhan State Medical University
Author for correspondence.
Email: nazim.gasanov.1985@mail.ru
Candidate of Medical Sciences, Assistant, Department of Surgical Diseases, Pediatric Faculty
Russian Federation, AstrakhanVladimir A. Bondarev
Astrakhan State Medical University
Email: nazim.gasanov.1985@mail.ru
Candidate of Medical Sciences, Associate Professor, Department of Surgical Diseases, Pediatric Faculty
Russian Federation, AstrakhanWaha-Haji A. Saydulaev
Astrakhan State Medical University
Email: nazim.gasanov.1985@mail.ru
Postgraduate Student, Department of Chemistry
Russian Federation, AstrakhanAlexander V. Bondarev
Astrakhan State Medical University
Email: Eidar_76@inbox.ru
Postgraduate Student, Department of Surgical Diseases, Pediatric Faculty
Russian Federation, AstrakhanReferences
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