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Post a Comment Role of connective tissue dysplasia in pathogenesis of diverticular disease
- Authors: Valinurov A.A.1,2, Chernyshova T.E.2, Styazhkina S.N.2
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Affiliations:
- City Clinical Hospital №7
- Izhevsk State Medical Academy
- Issue: Vol 40, No 4 (2023)
- Pages: 23-30
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/144144
- DOI: https://doi.org/10.17816/pmj40423-30
- ID: 144144
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Abstract
Objectives. To conduct a comparative analysis of the role of connective tissue dysplasia in the development of diverticular disease.
Materials and methods. At the screening stage of a single-stage study, clinical, functional, and radiological predictors of connective tissue dysplasia with diagnosed diverticular disease were evaluated. At the second stage of the study, a colonoscopy was performed. The disease was diagnosed by the combination of phenotypic signs of dysmorphic genesis.
Results. At the first stage, in 82 % of cases patients were concerned about their asthenic syndrome. Thirty-two patients with confirmed connective tissue dysplasia underwent colonoscopy. Diverticular disease was diagnosed in 28 patients (89.6 %).
Conclusions. High comorbidity of patients is associated with genetically determined disorders of connective tissue metabolism, manifested by a high frequency of diverticular formation. With a large number of diagnosed phenes, we can predict a rapid progression of diverticular disease. The frequency and severity are due to changes in the mechanical properties of the connective tissue of the submucosal layer.
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##article.viewOnOriginalSite##About the authors
A. A. Valinurov
City Clinical Hospital №7; Izhevsk State Medical Academy
Author for correspondence.
Email: mr-valinurov@yandex.ru
Deputy Chief Physician for Clinical and Experimental Work, postgraduate student of the Department of Faculty Surgery
Russian Federation, Izhevsk; IzhevskT. E. Chernyshova
Izhevsk State Medical Academy
Email: mr-valinurov@yandex.ru
MD, PhD, Professor, Department of General Practice with Courses of Emergency Care
Russian Federation, IzhevskS. N. Styazhkina
Izhevsk State Medical Academy
Email: mr-valinurov@yandex.ru
MD, PhD, Professor, Department of Faculty Surgery
Russian Federation, IzhevskReferences
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