Endogenous and exogenous risk factors for infection of premature new-borns with pathogens of purulent-septic infections
- Authors: Sheozheva A.V.1, Sergevnin V.I.2, Markovich N.I.3
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Affiliations:
- Adygea Republican Children's Clinical Hospital
- E.A. Vagner Perm State Medical University
- Perm Immunoprophylaxis Center
- Issue: Vol 40, No 4 (2023)
- Pages: 16-22
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/144143
- DOI: https://doi.org/10.17816/pmj40416-22
- ID: 144143
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Abstract
Objective. To identify the endogenous and exogenous risk factors for infection with pathogens of purulent-septic infections (PSI) in premature newborns in an obstetric hospital according to the data of routine microbiological monitoring.
Materials and methods. A bacteriological examination of 220 newborns (169 premature and 51 full-term) in resuscitation and intensive care unit (RICU) of the perinatal center was conducted. The same children were sampled on the day of admission to the RICU and on the 4th day of treatment. Biomaterial from the mucous membranes of the pharynx, nose, conjunctiva and umbilical fold was investigated in each child. The total number of samples was 1760.
Results. The frequency of isolation of microorganisms from premature newborns increased from 32.9 to 95.3 per 100 samples by the 4th day. It was 1.7 times higher in premature newborns than in full-term newborns. A statistically significant increase in the frequency of the release of PSI pathogens in premature newborns was found. It depended on the type of somatic pathology (undifferentiated intrauterine infection, respiratory disorders syndrome, perinatal central nervous system damage, intranatal asphyxia) and medical procedures (umbilical vascular catheterization, artificial lung ventilation, inhalation therapy, probe feeding).
Conclusions. The increased risk of infection with PSI pathogens in premature newborns in the RICU of the perinatal center is due to endogenous and exogenous risk factors.
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##article.viewOnOriginalSite##About the authors
A. V. Sheozheva
Adygea Republican Children's Clinical Hospital
Email: barhat120140@mail.ru
Epidemiologist
Russian Federation, MaikopV. I. Sergevnin
E.A. Vagner Perm State Medical University
Email: barhat120140@mail.ru
MD, PhD, Professor, Department of Epidemiology and Hygiene
Russian Federation, PermN. I. Markovich
Perm Immunoprophylaxis Center
Author for correspondence.
Email: barhat120140@mail.ru
MD, PhD, Chief Physician
Russian Federation, PermReferences
- Akimkin V.G., Tutelyan A.V. Current directions of scientific researches in the field of infections, associated with the medical care, at the present stage. Public Health and Habitat 2018; 4: 46–50 (in Russian).
- Zueva L.P., Liubimova A.V. Epidemiological problems of healthcare-associated infections. Preventive and Clinical Medicine 2017; 2 (63): 7–13 (in Russian).
- Lyubasovskaya L.A. Species composition of hospital strains of opportunistic microorganisms and their role in the development of infections in newborns with very low and extremely low body weight: Ph.D. dis. cand. honey. Sciences. Moscow 2013; 25 (in Russian).
- Markovich N.I., Sergevnin V.I., Sharafutdinova R.R. et al. Economic damage caused by major nosocomial pyoseptic infections in newborn babies and puerperas. Epidemiology and Infectious Diseases 2010; 4: 26–29. doi: 10.17816/EID40462 (in Russian)
- Sergevnin V.I., Horowitz E.S., Markovich N.I, et al. Nosocomial purulent-septic infections of newborns and puerperas (microbiological and epidemiological aspects). Perm 2010; 280 (in Russian).
- Sergevnin V.I., Klyuchareva N.M. Preepidemic diagnosis of incidence of nosocomial purulent-septic infections. Public Health and Habitat 2018; 1 (298): 27−29 (in Russian).
- Chikina O.G., Blagonravova A.S. Risks of developing infections associated with the provision of medical care when nursing newborns with extremely low and very low body weight. Medical Almanac 2017; 4 (49): 46–53 (in Russian).
- Bekker V., Bijlsma M.W., Beek D. Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study. The Lancet Infectious diseases 2014: 14 (11): 1083–1089. doi: 10.1016/S1473-99(14)70919-3
- Otter A., Vickery K., Walker J.T. et al. Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection. J. Hosp Infect. 2015: 89 (1): 16–27. doi: 10.1016/j.jhin.2014.09.008
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