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Post a Comment Results of catamnestic observation of cytomegalovirus infection in children
- Authors: Permyakova A.V.1, Pospelova N.S.1, Deryusheva A.Y.1
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Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 36, No 1 (2019)
- Pages: 91-96
- Section: Preventive and social medicine
- URL: https://journals.rcsi.science/PMJ/article/view/11668
- DOI: https://doi.org/10.17816/pmj36191-96
- ID: 11668
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Abstract
Aim. To study the characteristic features of cytomegalovirus excretion into the blood, saliva and urine of children aged 1-3 years with different forms of infectious process.
Materials and methods. There were analyzed the results of observation of 65 children aged 1-3 years with acute cytomegalovirus infection, who received ambulatory treatment and were observed in catamnesis of 6 months. Cytomegalovirus infection markers were determined in blood, saliva and urine serologically (IgM, IgG) and using the method of quantitative PCR.
Results. The maximum quantity of virus was found to be determined during the acute form of cytomegalovirus infection in the saliva, exceeding the value of 6.0 lg of CMV DNA copies/ml (median 4.9 lg of CMV DNA copies/ml). In the blood and urine of patients with the acute form of infection, the quantity of virus is within low and mean values of viral load (3.4 lg of CMV DNA copies/ml and 3.85 lg of CMV DNA copies/ml). Six month after the acute form of infection, no CMV DNA was determined in the blood, it decreased to 2.8 lg of CMV DNA copies/ml in the saliva and to 3.0 lg of CMV DNA copies/ml in the urine.
Conclusions. Thus, the amount of cytomegalovirus DNA in the biological media of the body such as blood, saliva and urine is maximal during the acute form of disease that can be used as a diagnostic method.
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##article.viewOnOriginalSite##About the authors
A. V. Permyakova
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: derucheva@mail.ru
кандидат медицинских наук, доцент кафедры детских инфекционных болезней
Russian Federation, 26, Petropavlovskay street, Perm, 614000N. S. Pospelova
E.A. Vagner Perm State Medical University
Email: kulikalova@mail.ru
ассистент кафедры детских инфекционных болезней
Russian Federation, 26, Petropavlovskay street, Perm, 614000A. Yu. Deryusheva
E.A. Vagner Perm State Medical University
Email: derucheva@mail.ru
студентка педиатрического факультета
Russian Federation, 26, Petropavlovskay street, Perm, 614000References
- Каражас Н.В., Малышев H.A., Рыбалкина Т.Н., Калугина М.Ю, Бошьян P.E. Кистенева Л.Б., Чешик С.Г., Мозанкова Л.Н. Герпес-вирусная инфекция (эпидемиология, клиника, диагностика, профилактика и лечение): метод. рекомендации. М. Спецкнига 2007; 28.
- Кистенева Л.Б., Чешик С.Г. Цитомегаловирусная инфекция и беременность: патогенез, диагностика, трактовка результатов обследования, лечение и профилактика. Инфекционные болезни: Новости. Мнения. Обучение 2017; 3 (20).
- Климова Р.Р., Околышева Н.В., Чичев Е.В., Тюленев Ю.А., Кистенева Л.Б., Малиновская В.В., Кущ А.А. Частота обнаружения герпес-вирусных инфекций у часто болеющих детей с острой респираторной инфекцией и их влияние на тяжесть заболевания. Педиатрия 2014; 93 (1): 44–49.
- Леготина Н.С., Львова И.И., Дерюшева А.В. Способ оценки эффективности терапии хронической цитомегаловирусной инфекции у детей: пат. Рос. Федерация № 2566074; 20.10.2015.
- Пермякова А.В., Львова И.И., Поспелова Н.С. О возможностях лабораторной верификации цитомегаловирусной инфекции у детей. Российский вестник перинатологии и педиатрии 2017; 62 (6): 45–50. doi: 10.21508/1027-4065-2017-62-6-45-50
- Руководство по вирусологии: вирусы и вирусные инфекции человека и животных. Под ред. акад. РАН Д.К. Львова. 2013; 1200.
- Cannon M.J., Stowell J.D., Clark R., Dollard P.R., Johnson D., Mask K. Repeated measures study of weekly and daily cytomegalo-virus shedding patterns in saliva and urine of healthy cytomegalovirus-seropositive children. BMC Infect Dis 2014; 14: 569.
- Cullis J. Anaemia of chronic disease. Clin Med 2013; 13 (2): 193–196.
- Halwachs-Baumann G., Genser B., Pailer S., Engele H. Human сytomegalovirus load in various body fluids of congenitally infected newborn. Austria. J ClinVirol 2002; 25(3): 81–87.
- Mayer B.T., Krantz E.M., Swan D., Ferrenberg J., Simmons K., Selke S., Huang M-L., Casper C., Corey L., Wald A., Schiffer J.T., Gantt S. Transient oral human cytomegalovirus infections indicate inefficient viral spread from very few initially infected cells. J Virol 2017; 91(12): e00380–17.
- Revellо M.G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin Microbiol Rev 2002; 15(4): 680–715.
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