Oncological risks of MTHFR, BRCA1 AND BRCA2 gene mutations in patients with chronic endometritis

Cover Page

Cite item

Full Text

Abstract

Aim. To assess the oncological risks for the MTHFR, BRCA1 and BRCA2 gene mutation in patients with chronic endometritis.

Materials and methods. Eighty six patients were examined: 33 practically healthy women and 53 patients with chronic endometritis. A part of the DNA of MTHFR (C677T, A1298C), BRCA1 (3361C > T), BRCA2 (Ser455Ser) genes was used as primers, ultrasound investigation of the mammary glands was implemented.

Results. Among patients with chronic endometritis, there was detected a high rate of benign mammary gland dysplasia, chronic pathology of gastrointestinal tract organs.

Conclusions. Patients with chronic endometritis have significant oncological risks, minor MTHFR and BRCA1 gene alleles were revealed in them more often than major ones, that, against the background of raised oncological pathology, acquires special significance.

About the authors

E. G. Kobaidze

E.A. Vagner Perm State Medical University

Author for correspondence.
Email: eka7i@yahoo.com

кандидат медицинских наук, доцент кафедры акушерства и гинекологии

Russian Federation, 26, Petropavlovskay street, Perm, 614000

References

  1. Габелова К.А., Потин В.В., Гзгзян А.М., Рулев В.В. Аутоиммунный оофорит (патогенез, клиника, диагностика, лечение): пособие для врачей. Н-Л.: 2010; 32.
  2. Гогсадзе Л.Г., Манухин И.Б., Пономарева Ю.Н. Клиническая значимость иммуноморфологического исследования рецепторов эстрогенов и прогестерона в комплексной диагностике хронического эндо метрита. Материалы XIV Всероссийского научного форума «Мать и дитя». М. 2013; 284–285.
  3. Дубницкая Л.В., Назаренко Т.А. Хронический эндометрит: возможности диагностики и лечения. Репродуктивное здоровье женщины 2007; 9(6): 7–10.
  4. Дюжева Е.В., Коган Е.А., Калинина Е.А. и др. Принципы индивидуальной гормональной подготовки эндометрия у пациенток с неэффективными попытками ЭКО. Акушерство и гинекология 2011; 7(2): 39–45.
  5. Ищенко Л.С. Клинико-морфологи ческие аспекты и пути оптимизации терапии хронического эндометрита: автореф. дис. … канд. мед. наук. Челябинск 2007; 25.
  6. Казачков Е.Л., Казачкова Э.А., Воропаева Е.Е., Хелашвили И.Г., Мирошниченко Л.Е. Структурная характеристика рецептивности эндометрия при хроническом эндометрите. Уральский медицинский журнал 2013; 109 (4): 60–64.
  7. Казачков Е.Л., Хелашвили И.Г., Казачкова Э.А., Воропаева Е.Е., Мирошниченко Л.Е. Хронический эндометрит, эндокринная функция яичников и рецептивность эндометрия: есть ли связь? Медицинский вестник Башкортостана 2014; 5 (9): 17–20.
  8. Протокол ведения больных – дисбактериоз кишечника. Приказ МЗ РФ № 231 от 09-06-2003. Отраслевой стандарт, available at: https://normativ.kontur.ru/document?modu leId = 1&documentId = 62571
  9. Рудакова Е.Б., Лобода О.А. Хронический эндометрит в аспекте результативности программ экстракорпорального оплодотворения. Лечащий врач 2012; 11: 22–24.
  10. Серебренникова К.Г., Кузнецова Е.П., Ванке Е.С. Подготовка эндометрия к программам ВРТ у пациенток с бесплодием. Проблемы репродукции 2014; 4: 62–67.
  11. Хашукоева А.З., Цомаева Е.А., Водяник Н.Д., Хлынова С.А. Хронический эндометрит – проблема и решения. Гинекология. Коллоквиум 2012; 3: 34–38.
  12. Atthill L. Clinical lecture on the treatment of chronic endometritis. The British Medical Journal 1878; 1: 779–780.
  13. Charalampakis V., Tahrani A.A., Helmy A., Gupta J.K., Singhal R. Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility. Eur J Obstet Gynecol Reprod Biol 2016; 207: 220–222.
  14. Chi Ma, Manoj Nepal, Jin-Hee Kim, Ping Fan, Peiwen Fei. A new look at molecular biology of breast cancer. Cancer Biology & Therapy 2018; 20(1): 1–5.
  15. Epplein M., Reed S.D., Voigt L., Newton K.M., Holt V.L., Weiss N.S. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am J Epidemiol 2008; 168 (6): 563–570.
  16. Fall S., Mercier A., Bertolla F. Horizontal gene transfer regulation in acteria as a «spandrel» of DNA repair mechanisms. PLoS ONE 2007; 2(10): 1055.
  17. Goukassian D.A., Gilchrest B.A. The interdependence of skin aging, skin cancer, and DNA repair capacity: a novel perspective with therapeutic implications. Rejuvenation Res 2004; 7(3): 175–185.
  18. Hall C.B., Caserta M.T., Schnabel K. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics 2008; 122(3): 513–520.
  19. Huo Y., Li J., Qin X., Huang Y., Wang X., Gottesman R.F., Tang G., Wang B., Chen D., He M. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: The CSPPT randomized clinical trial. JAMA 2015; 313: 1325–1335.
  20. Husemoen L.L., Skaaby T., Jorgensen T., Thuesen B.H., Fenger M., Grarup N., Sandholt C.H., Hansen T., Pedersen O., Linneberg A. MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification. Eur J Nutr 2014; 53: 1549–1559.
  21. Marshall T.G. Understanding human disease requires study of a metagenome, not just the human genome. World Gene Congress 2008; December 5–7; Foshan, China: available at: http://autoimmunityresearch.org/trans cripts/WCG2008_Keynote_Transcript.pdf
  22. Paulson R.J. Hormonal induction of endometrial receptivity. Fertil Steril 2011; 96 (3); 530–535.
  23. Peipert J.F., Ness R.B., Blume J. Pelvic inflammatory disease evaluation and clinical health study investigators. Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease. Am J Obstet Gynecol 2001; 184 (5): 856–863.
  24. Price T.K., Dune T., Hilt E.E., Thomas-White K.J., Kliethermes S., Brincat C., Brubaker L., Wolfe A.J., Mueller E.R., Schreckenbergere P.C. The clinical urine culture: enhanced techniques improve detection of clinically relevant microorganisms. Journal of Clinical Microbiology 2016; 54; 5: 1216–1222.
  25. Schwabe R.F., Jobin C. The microbiome and cancer. Nat Rev Cancer 2013; 13(11): 800–812.
  26. Siiteri P.K. Adipose-tissue as a source of hormones. Am J Clin Nutr 1987; 45(1): 277–282.
  27. Trautmann G.M., Kip K.E. Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease? Am J Obstet Gynecol 2008; 1–7.
  28. Upala S., Sanguankeo A. Bariatric surgery and risk of postoperative endometrial cancer: a systematic review and meta-analysis. Surg Obes Relat Dis 2015; 11 (4).
  29. Verhelst R., Verstraelen H., Claeys G. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol 2004; 4: 16.
  30. Zappacosta B., Mastroiacovo P., Persichilli S., Pounis G., Ruggeri, S., Minucci A., Carnovale E., Andria G., Ricci R., Scala I. Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia. Nutrients 2013; 5: 1531–1543.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Results of ultrasound examination of the mammary gland (MF) in groups

Download (67KB)
Indexing metadata
3. Fig. 2. Polymorphism of the gene MTHFR (rs 1801133) C677T in groups

Download (29KB)
Indexing metadata
4. Fig. 3. Polymorphism of the BRCA1 gene (a) and BRCA2 in groups (* p <0.001)

Download (62KB)
Indexing metadata

Copyright (c) 2019 Kobaidze E.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies