Email this article 
Post a Comment Synthesis and study of psychotropic activity spectrum of 4-aryl-2-benzoylmethylenehydrazono-4-oxobutanoic acids
- Authors: Pulina N.A.1, Krasnova A.I.1, Kuznetsov A.S.1, Naugolnykh E.A.1
-
Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 39, No 4 (2022)
- Pages: 65-70
- Section: Clinical studies
- URL: https://journals.rcsi.science/PMJ/article/view/110801
- DOI: https://doi.org/10.17816/pmj39465-70
- ID: 110801
Cite item
Full Text
Abstract
Objective. To study psychotropic activity of 4-aryl-2-benzoylmethylenhidrazono-4-oxobutanoic acids, as well as to determine the relationship between the structure of substances and their biological activity.
Materials and methods. The spectrum of psychotropic activity of 4-aryl-2-benzoylmethylenehydrazono-4-oxobutanoic acids was studied on experimental animals using the open field, black-and-white camera, and extrapolation deliverance tests.
Results. Psychopharmacological effects of various severity and direction were revealed. Two compounds showed anxiogenic properties without deterioration in cognitive potential, one substance displayed a trend to anxiolytic activity. The effect of the certain radicals in the structure of the substances on the studied activities was found.
Conclusions. The obtained links between the structure of original compounds and their psychotropic action can be used in further targeted synthesis and search for new domestic pharmaceutical substances with investigated effects in a series of derivatives of 2,4-dioxobutanoic acids.
Full Text
##article.viewOnOriginalSite##About the authors
N. A. Pulina
Perm State Pharmaceutical Academy
Author for correspondence.
Email: pulina-nata@mail.ru
Doctor of Pharmaceutical Science, Professor, Head of Department of Pharmaceutical Technology
Russian Federation, PermA. I. Krasnova
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Pharmaceutical Science, Associate Professor, Department of Pharmacology
Russian Federation, PermA. S. Kuznetsov
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Pharmaceutical Sciences, Associate Professor, Department of General and Organic Chemistry
Russian Federation, PermE. A. Naugolnykh
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Philological Sciences, Associate Professor, Department of Foreign Languages
Russian Federation, PermReferences
- Stein D.J., He Y., Phillips A., Sahakian B.J., Williams J., Patel V. Global mental health and neuroscience: potential synergies. Lancet Psychiatry 2015; 2 (2): 178–85.
- Kuznetsov A.S., Sobin F.V., Kozhukhar V.Yu., Pulina N.A. Evaluation of the prospects of searching for biologically active compounds in the series of 4-R-2-hydroxy-4-oxo-2-butenoic acid derivatives. Global Science Capacity 2013; 4: 8–11 (in Russian).
- Pulina N.A., Kuznetsov A.S., Krasnova A.I., Novikova V.V. Synthesis, antimicrobial activity, and behavioral response effects of N-substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid hydrazides and their metal complexes. Pharmaceutical chemistry journal 2019; 53 (3): 220–224 (in Russian).
- Pulina N.A., Kuznetsov A.S., Chaschina S.V. Studying of analgesic and antiinflammatory activity of 2,4-dioxobutanoic acid. Permskiy meditsinskiy zhurnal 2020; 37 (4): 115–119 (in Russian).
- Pulina N.A., Zalesov V.V., Bystritskaya O.A., Rubtsov A.E., Kutkovaya N.V. Synthesis and biological activity of substituted 4-aryl-2-methylenehydrazino-4-oxobut-2-enoic acids and their derivatives. Pharmaceutical chemistry journal 2009; 43 (8): 444–447 (in Russian).
- Bykov R.A., Balandina S.Y., Komarova O.A., Makhmudov R.R., Sobin F.V., Rubtsov A.E., Trapeznikova N.N., Pulina N.A. Synthesis and biological activity of 4-aryl-2-[(2-oxo-1,2-diphenylethylidene)-hydrazinyl]-4-oxobut-2-enoic-acid amides. Pharmaceutical chemistry journal 2018; 53 (3): 220–224 (in Russian).
- State Pharmacopoeia of the Russian Federation of the Ministry of Health of the Russian Federation 14th ed. Мoscow 2018; 1: 1814 (in Russian).
- Guidelines for conducting preclinical studies of drugs. Part One. Pod red. A.N. Mironova. Мoscow: Grif i K 2013; 944 (in Russian).
Supplementary files
