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Post a Comment Liver cirrhosis
- Authors: Shchyokotova A.P.1
-
Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 39, No 4 (2022)
- Pages: 41-57
- Section: Review of literature
- URL: https://journals.rcsi.science/PMJ/article/view/110788
- DOI: https://doi.org/10.17816/pmj39441-57
- ID: 110788
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Abstract
The liver cirrhosis (LC) is a severe disease, the 11th by the cause of death in the world, 50 % of patients die during 5 years. The most frequent etiological factors are alcoholic disease of the liver and chronic viral hepatitis. The following general pathological mechanisms are involved in LC pathogenesis: hepatocyte damage, endothelial dysfunction, oxidant stress, fibrosis activation, pathological regeneration, neoangiogenesis, architectonic impairment of the organ with the development of portal hypertension. Genetic factors contribute to the progression of the liver pathology. Depending on the LC etiology, there are the features of pathogenesis, clinical picture, morphology, diagnostics, treatment and prognosis for alcoholic liver disease, chronic viral hepatitis, nonalcoholic fat liver disease, autoimmune hepatitis, primary biliary LC, hemochromatosis, Wilson-Konovalov disease, A1-antitripcin deficiency disease. Among rare causes of LC, there are noted Budd-Chiari syndrome, cardiac cirrhosis, Indian childhood cirrhosis.
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##article.viewOnOriginalSite##About the authors
A. P. Shchyokotova
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: al_shchekotova@mail.ru
MD, PhD, Associate Professor, Professor of Department of Faculty Therapy № 2, Occupational Pathology and Clinical Laboratory Diagnostics
Russian Federation, PermReferences
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