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Post a Comment Changed content of heat shock proteins and antibodies to them in blood and nasal mucosa cells in rhinites and rhinosinusites of different etiology
- Authors: Ivanov M.O.1, Ivanova N.M.1, Maksimenya M.V.1, Karavaeva T.M.1, Egorova E.V.1, Fefelova E.V.1, Tsybikov N.N.1
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Affiliations:
- Chita State Medical Academy
- Issue: Vol 35, No 6 (2018)
- Pages: 23-28
- Section: Methods of diagnosis and technologies
- URL: https://journals.rcsi.science/PMJ/article/view/10344
- DOI: https://doi.org/10.17816/pmj35623-28
- ID: 10344
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Abstract
Aim. To determine the content of heat shock proteins with molecular weight 70 kDa (HSP 70) and antibo dies to them in blood and nasal secretion in patients with allergic rhinites and infectious rhinosinusites of different etiology.
Materials and methods. The paper presents the results of examination of 10 patients with allergic rhinitis and 30 patients, infected with rhinosinusites(the age range 25–35 years). The patients with infectious rhinosinusites were divided into 3 groups according to nosologic form of disease. The control group included 10 practically healthy persons in the ratio, comparable by their gender and age with sick persons.
Results.The analysis showed that in the nasal secretion of all patients, HSP 70 level significantly raised compared to the control. Maximum values were registered in patients with bacterial rhinosinusitis and were higher than in patients with viral and fungous ones by 1.9 times (p = 0.015) and 2.9 times (p = 0.001), respectively. In blood serum, HSP 70 concentration compared with the control increased in patients with allergic rhinitis and bacterial rhinosinusitis by 103.67 % (p = 0.015) and 32.11 % (p = 0.049), respectively; these values in the last two groups exceeded the latter in patients with fungous RS by 2.37 times (p = 0.01) and by 1.54 times (p = 0.035).
Conclusions. It was detected that in the group of patients with allergic rhinitis and chronic bacterial rhinosinusitis in the nasal secretion and blood serum, HSP 70 values were the highest. In the nasal secretion, HSP 70 level was higher than in blood. The amount of autoantibodies to HSP 70 in blood grew in allergic rhinitis, fungous and viral forms of rhinosinusites that reflects the immunological effect of chaperone proteins.
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##article.viewOnOriginalSite##About the authors
M. O. Ivanov
Chita State Medical Academy
Author for correspondence.
Email: ivanov5826@yandex.ru
SPIN-code: 8578-0087
Scopus Author ID: 884455
аспирант кафедры патологической физиологии, врач-оториноларинголог
Russian Federation, 39a, Gorky street, Chita, 672000N. M. Ivanova
Chita State Medical Academy
Email: 89148008008@mail.ru
SPIN-code: 4038-6513
Scopus Author ID: 884246
аспирант кафедры патологической физиологии, врач-дерматовенеролог
Russian Federation, 39a, Gorky street, Chita, 672000M. V. Maksimenya
Chita State Medical Academy
Email: pochta@medacadem.chita.ru
SPIN-code: 1875-5786
Scopus Author ID: 374841
кандидат медицинских наук, заведующий биохимической лабораторией
Russian Federation, 39a, Gorky street, Chita, 672000T. M. Karavaeva
Chita State Medical Academy
Email: pochta@medacadem.chita.ru
SPIN-code: 5483-1547
Scopus Author ID: 750419
старший научный сотрудник биохимической лаборатории
Russian Federation, 39a, Gorky street, Chita, 672000E. V. Egorova
Chita State Medical Academy
Email: egorovaelen@mail.ru
SPIN-code: 2670-7160
Scopus Author ID: 769223
доктор медицинских наук, заведующий кафедрой оториноларингологии
Russian Federation, 39a, Gorky street, Chita, 672000E. V. Fefelova
Chita State Medical Academy
Email: fefelova.elena@mail.ru
SPIN-code: 4199-2842
Scopus Author ID: 520408
кандидат медицинских наук, доцент кафедры патологической физиологии
Russian Federation, 39a, Gorky street, Chita, 672000N. N. Tsybikov
Chita State Medical Academy
Email: thybikov@mail.ru
SPIN-code: 1963-8418
Scopus Author ID: 520407
доктор медицинских наук, профессор, заведующий кафедрой патологической физиологии
Russian Federation, 39a, Gorky street, Chita, 672000References
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