Diagnostic value of lung ultrasound in COVID-19: systematic review and meta-analysis
- Authors: Vetsheva N.N.1,2, Reshetnikov R.V.1,3, Leonov D.V.1, Kulberg N.S.1, Mokienko O.A.1
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Affiliations:
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
- Moscows regional research clinical institute n.a. M.F. Vladimirskiy
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 1, No 1 (2020)
- Pages: 13-26
- Section: Systematic reviews
- URL: https://journals.rcsi.science/DD/article/view/46834
- DOI: https://doi.org/10.17816/DD46834
- ID: 46834
Cite item
Abstract
BACKGROUND: Effective and safe tools assisting triage decisions for COVID-19 patients could optimize the pressure on the healthcare system. COVID-19 often has respiratory manifestations, and medical imaging techniques provide an opportunity to assess the disease’s severity.
AIMS: To estimate the sensitivity and specificity of lung ultrasound for different degrees of pulmonary involvement in COVID-19 patients by a systematic review of English articles using PubMed and Google Scholar databases. Search terms included lung ultrasound, chest ultrasound, thoracic ultrasound, ultrasonography, COVID-19, SARS-CoV-2, coronavirus, diagnosis, diagnostic value, specificity, and sensitivity. Only studies addressing lung ultrasound diagnostic accuracy for patients with suspected COVID-19 using thoracic computed tomography, reverse transcription polymerase chain reaction, or laboratory data as a reference standard were included. Independent extraction of articles was performed by two authors using predefined data fields with subsequent assessment of study quality indicators. The random-effect model was used to analyze and pool lung ultrasound sensitivity and specificity across the included studies. Sixteen studies met our inclusion criteria, but only three of them divided patients into distinct and defined groups depending on the disease severity. We used the remaining studies’ data to assess the secondary outcomes: the values of sensitivity and specificity of lung ultrasound for COVID-19 regardless of the patient’s clinical status. Heterogeneity for primary and secondary outcomes was observed that remained when pooling for different scenarios (screening, assessing severity) and cohorts of participants. Lung ultrasound had the highest accuracy for confirmed COVID-19 patients with severe disease (sensitivity 87.6% ± 12.3%, specificity 80.5% ± 7.1%), and the lowest accuracy for the patients with mild disease (sensitivity 72.8% ± 7.1%, specificity 74.3% ± 2.7%).
CONCLUSIONS: Lung ultrasound can be used in patients with confirmed COVID-19 to detect serious damage to the lung tissue. The diagnostic value of the method for assessing mild and moderate lung lesions is relatively low.
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##article.viewOnOriginalSite##About the authors
Natalia N. Vetsheva
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department; Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Author for correspondence.
Email: vetsheva@npcmr.ru
ORCID iD: 0000-0002-9017-9432
SPIN-code: 9201-6146
MD, PhD
Russian Federation, MoscowRoman V. Reshetnikov
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department; Sechenov First Moscow State Medical University (Sechenov University)
Email: reshetnikov@fbb.msu.ru
ORCID iD: 0000-0002-9661-0254
SPIN-code: 8592-0558
PhD
Russian Federation, MoscowDenis V. Leonov
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Email: d.leonov@npcmr.ru
ORCID iD: 0000-0003-0916-6552
SPIN-code: 5510-4075
PhD
Russian Federation, MoscowNikolas S. Kulberg
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Email: kulberg@npcmr.ru
ORCID iD: 0000-0001-7046-7157
SPIN-code: 2135-9543
PhD
Russian Federation, MoscowOlesya A. Mokienko
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Email: o.mokienko@npcmr.ru
ORCID iD: 0000-0002-7826-5135
SPIN-code: 8088-9921
MD, PhD
Russian Federation, MoscowReferences
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