ENANTIOSELECTIVE BIOREDUCTION OF PROCHIRAL AROMATIC AND HETEROAROMATIC KETONES CATALYZED BY DAUCUS CAROTA AND PETROSELINUM CRISPUM CELLS

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Abstract

A convenient method for the synthesis of optically pure secondary heteroaromatic S-alcohols by asymmetric reduction of prochiral heteroaromatic ketones catalyzed by D. carota or P. crispum cells has been developed. Using o-, m-, p-bromophenylethanone as an example, we studied the effect of the substituent position in the aromatic ring of acetophenone on the efficiency and stereoselectivity of carbonyl group bioreduction by D. carota and P. crispum catalysts.

About the authors

A. R Chanysheva

Ufa State Petroleum Technological University

Email: aliyach@mail.ru
450062 Ufa, Russian Federation

N. V Privalov

Ufa State Petroleum Technological University

450062 Ufa, Russian Federation

V. V Peperva

Ufa State Petroleum Technological University

450062 Ufa, Russian Federation

V. V Zorin

Ufa State Petroleum Technological University

450062 Ufa, Russian Federation

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