Anti-tumor activity of cobalt-containing complexes of potassium and sodium polygalacturonates and pharmacological compositions based on them

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Abstract

Based on the method developed in this study for obtaining water-soluble PGKCo and PGNaCo, which we had previously synthesized, a pharmacological composition (PC) containing simultaneously the macroelements K and Na, as well as the trace element Co, was obtained for the first time. The effect of polygalacturonates and PC on the viability of cells of tumor lines of various origins was studied in vitro. It was shown that the target products have water solubility, low toxicity (LD50 above 5000 mg kg–1) and selective cytotoxic activity against the tumor cell line of human lung carcinoma A549, breast adenocarcinoma MCF-7 and cervical carcinoma M-HeLa. The results obtained confirm the prospects for further research into water-soluble metal complexes and PC based on pectin biopolymers for the treatment of cancer.

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About the authors

S. T. Minzanova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Author for correspondence.
Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

E. V. Chekunkov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

A. D. Voloshina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

L. G. Mironova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

A. V. Khabibullina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

V. A. Milyukov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru
Russian Federation, 420088, Kazan

V. F. Mironov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: minzanova@iopc.ru

Corresponding Member of the RAS

Russian Federation, 420088, Kazan

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Supplementary files

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1. JATS XML
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2. Fig. 1. Schematic diagram of the preparation of PGKSo, PGNaCo and the pharmacological composition of PGKSo/PGNaCo.

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3. Scheme 1. The scheme for obtaining the PGKSo compound.

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