Anti-tumor activity of cobalt-containing complexes of potassium and sodium polygalacturonates and pharmacological compositions based on them
- 作者: Minzanova S.1, Chekunkov E.1, Voloshina A.1, Mironova L.1, Khabibullina A.1, Milyukov V.1, Mironov V.1
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隶属关系:
- Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
- 期: 卷 515, 编号 1 (2024)
- 页面: 36–44
- 栏目: CHEMICAL TECHNOLOGY
- URL: https://journals.rcsi.science/2686-9535/article/view/259117
- DOI: https://doi.org/10.31857/S2686953524020044
- EDN: https://elibrary.ru/zryssq
- ID: 259117
如何引用文章
详细
Based on the method developed in this study for obtaining water-soluble PGKCo and PGNaCo, which we had previously synthesized, a pharmacological composition (PC) containing simultaneously the macroelements K and Na, as well as the trace element Co, was obtained for the first time. The effect of polygalacturonates and PC on the viability of cells of tumor lines of various origins was studied in vitro. It was shown that the target products have water solubility, low toxicity (LD50 above 5000 mg kg–1) and selective cytotoxic activity against the tumor cell line of human lung carcinoma A549, breast adenocarcinoma MCF-7 and cervical carcinoma M-HeLa. The results obtained confirm the prospects for further research into water-soluble metal complexes and PC based on pectin biopolymers for the treatment of cancer.
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作者简介
S. Minzanova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
E. Chekunkov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
L. Mironova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
A. Khabibullina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
V. Milyukov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
俄罗斯联邦, 420088, Kazan
V. Mironov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences
Email: minzanova@iopc.ru
Corresponding Member of the RAS
俄罗斯联邦, 420088, Kazan参考
- Huang X., Li S., Ding R., Li Y., Li C., Gu R. // Int. J. Biol. Macromol. 2023. V. 252. Article 126313. https://doi.org/10.1016/j.ijbiomac.2023.126313
- Садовская Н.Ю., Глушко В.Н., Блохина Л.И., Ретивов В.М. // Хим. безопасность. 2020. Т. 4. № 2. P. 80–100. https://doi.org/10.25514/CHS.2020.2.18006
- Kar K., Ghosh D., Kabi B., Chandra A. // Polyhedron. 2022. V. 222. Article 115890. https://doi.org/10.1016/j.poly.2022.115890
- Law B.Yu.K., Qu Yu.Q., Mok S.W.F., Liu H., Zeng W., Han Yu., Gordillo-Martinez F., Chan W.-K., Wong K.M.-Ch., Wong V.K.W. // Oncotarget. 2017. V. 8. № 33. P. 55003–55021. https://doi.org/10.18632/oncotarget.18991
- Dasari S., Tchounwou P.B. // Eur. J. Pharmacol. 2014. V. 740. P. 364–378. https://doi.org/10.1016/j.ejphar.2014.07.025
- Heffern M.C., Yamamoto N., Holbrook R.J., Eckermann A.L., Meade T.J. // Curr. Opin. Chem. Biol. 2013. V. 17. № 2. P. 189–196. https://doi.org/10.1016/j.cbpa.2012.11.019
- El-bendary M.M., Akhdhar A., Ali E.M.M., Kalantan A.A., Davaasuren B., Jaremko M., Babgi B.A. // Polyhedron. 2023. V. 242. Article 116511. https://doi.org/10.1016/j.poly.2023.116511
- Dasgupta S., Kar K., Barua A., Ghosh D., Kabi B., Dewan K., Chandra A. // Life Sci. 2022. V. 308. Article 120963. https://doi.org/10.1016/j.lfs.2022.120963
- Авцын А.П., Жаворонков А.А., Риш М.А. Микроэлементозы человека: (Этиология, классификация, органопатология). М.: Медицина, 1991. 496 с.
- Lison D., van den Brule S., Van Maele-Fabry G.V. // Crit. Rev. Toxicol. 2018. V. 48. № 7. P. 522–539. https://doi.org/10.1080/10408444.2018.1491023
- Minzanova S.T., Mironov V.F., Arkhipova D.M., Khabibullina A.V., Mironova L.G., Zakirova Yu.M., Milyukov V.A. // Polymers. 2018. V. 10. № 12. Article 1407. https://doi.org/10.3390/polym10121407
- Yue Y., Wang B., Xi W., Liu X., Tang Sh., Tan X., Li G., Huang L., Liu Y., Bai J. // Int. J. Biol. Macromol. 2023. V. 253. № 8. Article 127523. https://doi.org/10.1016/j.ijbiomac.2023.127523
- Khotimchenko M. // Int. J. Biol. Macromol. 2020. V. 158. P. 1110–1124. https://doi.org/10.1016/j.ijbiomac.2020.05.002
- Maxwell E.G., Colquhoun I.J., Chau H.K., Hotchkiss A.T., Waldron K.W., Morris V.J., Belshaw N.J. // Carbohydr. Polym. 2015. V. 132. P. 546–553. https://doi.org/10.1016/j.carbpol.2015.06.082
- Zhang W., Xu P., Zhang H. // Trends Food Sci. Tech. 2015. V. 44. P. 258–271. https://doi.org/10.1016/j.tifs.2015.04.001
- Cheewatanakornkool K., Niratisai S., Manchun S., Dass C.R., Sriamornsak P. // Asian J. Pharm. Sci. 2017. V. 12. P. 509–520. https://doi.org/10.1016/j.ajps.2017.07.005
- Cheewatanakornkool K., Niratisai S., Manchun S., Dass C.R., Sriamornsak P. // Carbohydr. Polym. 2017. V. 174. P. 493–506. https://doi.org/10.1016/j.carbpol.2017.06.115
- Minzanova S.T., Mironov V.F., Vyshtakalyuk A.B., Tsepaeva O.V., Mironova L.G., Mindubaev A.Z., Nizameev I.R., Kholin K.V., Milyukov V.A. // Carbohydr. Polym. 2015. V. 134. P. 524–533. https://doi.org/10.1016/j.carbpol.2015.07.034
- Minzanova S.T., Chekunkov E.V., Khabibullina A.V., Vyshtakalyuk A.B., Kholin K.V., Mironova L.G., Nizameeva G.R., Khamatgalimov A.R., Ryzhkina I.S., Murtazina L.I., Milyukov V.A. // Russ. Chem. Bull. 2023. V. 72. P. 2263–2277. https://doi.org/10.1007/s11172-023-4024-6
- Minzanova S.T., Arkhipova D.M., Khabibullina A.V., Mironova L.G., Voloshina A.D., Sapunova A.S., Kulik N.V., Milyukov V.A., Mironov V.F. // Dokl. Chem. 2019. V. 487. № 2. P. 207–211. https://doi.org/10.1134/S0012500819080044
- Машковский М.Д. Лекарственные средства. 16-е изд. М.: Новая Волна. 2012. 1216 с.
- Reuter H., Pott Ch., Goldhaber J.I., Henderson S.A., Philipson K.D., Schwinger R.H.G. // Cardiovas. Res. 2005. V. 67. № 2. P. 198–207. https://doi.org/10.1016/j.cardiores.2005.04.031
- Mijatovic T., Ingrassia L., Facchini V., Kiss R. // Expert Opin. Ther. Targets. 2008. V. 12. № 11. P. 1403–1417. https://doi.org/10.1517/14728222.12.11.1403
- Wang R., Liang R., Dai T., Chen J., Shuai X., Liu Ch. // Trends Food Sci. Technol. 2019. V. 91. P. 319–329. https://doi.org/10.1016/j.tifs.2019.07.033
- ГОСТ 12.1.007-76. ССБТ. Вредные вещества. Классификация и общие требования безопасности. Утвержден и введен в действие Постановлением Государственного комитета СССР по стандартам от 10.03.76 № 579. Дата введения 01.01.1977.
- Ayoup M., Wahby Y., Abdel-Hamid H., Ramadan E., Teleb M., Abu-Serie M., Noby A. // Eur. J. Med. Chem. 2019. V. 168. P. 340–356. https://doi.org/10.1016/j.ejmech.2019.02.051
- Voloshina A.D., Semenov V.E., Strobykina A.S., Kulik N.V., Krylova E.S., Zobov V.V., Reznik V.S. // Russ. J. Bioorg. Chem. 2017. V. 43. № 2. P. 170–176. https://doi.org/10.1134/S1068162017020170
- Peña-Morán O.A., Villarreal M.L., Álvarez-Berber L., Meneses-Acosta A., Rodríguez-López V. // Molecules. 2016. V. 21. № 8. P. 1013. https://doi.org/10.3390/molecules21081013
- Руководство по проведению доклинических исследований лекарственных средств. Часть 1. Миронов А.Н. (ред.). М.: Гриф и К, 2012. 944 с.