SUPER-SENSITIVE REGISTRATION OF POLYFUNCTIONAL MAGNETIC NANOMATERIALS FOR THE RAPID DETERMINATION OF MOLECULAR MARKERS OF DISEASES
- Authors: Orlov A.V.1, Malkerov Y.A.1,2, Skirda A.M.1,2, Novichikhin D.O.1,2, Znoyko S.L.1, Bragina V.A.1, Nikitin P.I.1
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Affiliations:
- Prokhorov General Physics Institute of the Russian Academy of Sciences
- National Research Nuclear University MEPhI
- Issue: Vol 511, No 1 (2023)
- Pages: 22-28
- Section: ФИЗИКА
- URL: https://journals.rcsi.science/2686-7400/article/view/135934
- DOI: https://doi.org/10.31857/S2686740023040107
- EDN: https://elibrary.ru/VMFQOY
- ID: 135934
Cite item
Abstract
Magnetic particles (MPs) based on superparamagnetic iron oxide nanocrystals are increasingly used in modern research for the development of express technologies for high-precision determination of the concentration of biomolecules. In this work, we developed a universal method for using MPs as polyfunctional agents that perform several different functions in one analysis for topical issues of biochemical and medical diagnostics, based on the original technology of ultrasensitive detection of nonlinear magnetic nanomaterials. The method was tested for the rapid quantitative registration of cardiac markers and SARS-CoV-2-associated molecular markers in complex matrices. The proposed method is promising for creating test systems for prehospital monitoring, particularly for emergency molecular diagnostics in patients with suspected acute myocardial infarction, as well as for the rapid detection of coronavirus infection.
Keywords
About the authors
A. V. Orlov
Prokhorov General Physics Institute of the Russian Academy of Sciences
Author for correspondence.
Email: alexey.orlov@kapella.gpi.ru
Russia, Moscow
Yu. A. Malkerov
Prokhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow; Russia, Moscow
A. M. Skirda
Prokhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow; Russia, Moscow
D. O. Novichikhin
Prokhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow; Russia, Moscow
S. L. Znoyko
Prokhorov General Physics Institute of the Russian Academy of Sciences
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow
V. A. Bragina
Prokhorov General Physics Institute of the Russian Academy of Sciences
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow
P. I. Nikitin
Prokhorov General Physics Institute of the Russian Academy of Sciences
Author for correspondence.
Email: petr.nikitin@nsc.gpi.ru
Russia, Moscow
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