THE EFFECT OF THE AGONIST CHOLECYSTOKININ-4 D-GB-115 ON THE CHARACTER OF MOTOR ACTIVITY OF PARAMECIUM CAUDATUM
- 作者: Gruzdev G.1, Soboleva L.1, Kamensky A.1
-
隶属关系:
- Lomonosov Moscow State University
- 期: 卷 510, 编号 1 (2023)
- 页面: 263-267
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135694
- DOI: https://doi.org/10.31857/S2686738923600024
- EDN: https://elibrary.ru/QHLRZY
- ID: 135694
如何引用文章
详细
The study investigated the effect of GABA in various concentrations and D-GB-115 at a concentration of 10–10 mol/ml on the behavior of Paramecium caudatum. It has been shown that GABA increases motor activity and changes the movement strategy of these protozoa, and the dose-effect relationship is domed, which can be explained by the presence of two types of GABA receptors in the outer membrane of paramecia: GABA-A and GABA-B. The range of active concentrations of GABA ranges from 10–6 to 10–16 mol/ml. The effect of pharmacological agents interacting with the GABA system on the behavior of infusoria: nembutal and D-GB-115.
作者简介
G. Gruzdev
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: Gleb-neuro.phys@mail.ru
Russian Federation, Moscow
L. Soboleva
Lomonosov Moscow State University
Email: Gleb-neuro.phys@mail.ru
Russian Federation, Moscow
A. Kamensky
Lomonosov Moscow State University
Email: Gleb-neuro.phys@mail.ru
Russian Federation, Moscow
参考
- Hobson-West P., Davies A. Societal Sentience: Constructions of the Public in Animal Research Policy and Practice // Sci Technol Human Values. 2018. V. 43. № 1. P. 671–693.
- Gruzdev G.A., Karpukhina O.V., Yakunin V.G., et al. Effect of Low-Temperature Atmospheric Pressure Plasma on Paramecium caudatum Cell Culture // Moscow Univ Biol Sci Bull. 2022. V. 76. P. 244–248.
- Gruzdev G.A., Karpukhina O.V., Inozemtsev A.N., et al. Method for Primary Screening of Pharmaceuticals on the Paramecium caudatum Eukaryotic Cell Model // Dokl Biochem Biophys. 2022. V. 502. P. 36–39.
- Gudasheva T.A., Kir’Yanova E.P., Kolik L.G., et al. Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities // Russ J Bioorganic Chem. 2007. V. 33. P. 383–389.
- Schindelin J., Arganda-Carreras I., Frise E., et al. Fiji: An open-source platform for biological-image analysis // Nat. Methods. 2012. V. 9. P. 676–682.
- Груздев Г.А., Карпухина О.В., Иноземцев А.Н., et al. Анализ двигательной активности инфузорий Paramecium caudatum как тест-система оценки свойств адреналина // Экспериментальная и клиническая фармакология V. 85. P. 41–45.
- Schlaepfer C.H., Wessel R. Excitable Membranes and Action Potentials in Paramecia: An Analysis of the Electrophysiology of Ciliates // J Undergrad Neurosci Educ. 2015. V. 14. № 1. P. 82–6.
- Ramoino P., Milanese M., Candiani S., et al. Gamma-amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis // J Exp Biol. 2010. V. 213. P. 1251–8.
- Germann A.L., Burbridge A.B., Pierce S.R., et al. Activation of the Rat α1β2ε GABA-A Receptor by Orthosteric and Allosteric Agonists // Biomolecules. 2022. V. 12. P. 1–16.
- Csaba G. The hormonal system of the unicellular Tetrahymena: a review with evolutionary aspects // Acta Microbiol Immunol Hung. 2012. V. 59. P. 131–156.
- Siniscalchi A., Rodi D., Cavallini S., et al. Effects of cholecystokinin tetrapeptide (CCK4) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats // Neurochem Int. 2003. V. 42. P. 87–92.
![](/img/style/loading.gif)