THE EFFECT OF THE AGONIST CHOLECYSTOKININ-4 D-GB-115 ON THE CHARACTER OF MOTOR ACTIVITY OF  PARAMECIUM CAUDATUM

G. A. Gruzdev; Груздев Г. А.; L. V. Soboleva; Соболева Л. В.; A. A. Kamensky; Каменский А. А.

doi:10.31857/S2686738923600024

THE EFFECT OF THE AGONIST CHOLECYSTOKININ-4 D-GB-115 ON THE CHARACTER OF MOTOR ACTIVITY OF PARAMECIUM CAUDATUM

Authors: Gruzdev G.A.¹, Soboleva L.V.¹, Kamensky A.A.¹
Affiliations:
1. Lomonosov Moscow State University
Issue: Vol 510, No 1 (2023)
Pages: 263-267
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135694
DOI: https://doi.org/10.31857/S2686738923600024
EDN: https://elibrary.ru/QHLRZY
ID: 135694

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Abstract
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Abstract

The study investigated the effect of GABA in various concentrations and D-GB-115 at a concentration of 10^–10 mol/ml on the behavior of Paramecium caudatum. It has been shown that GABA increases motor activity and changes the movement strategy of these protozoa, and the dose-effect relationship is domed, which can be explained by the presence of two types of GABA receptors in the outer membrane of paramecia: GABA-A and GABA-B. The range of active concentrations of GABA ranges from 10^–6 to 10^–16 mol/ml. The effect of pharmacological agents interacting with the GABA system on the behavior of infusoria: nembutal and D-GB-115.

Keywords

paramecium caudatum, comparative physiology, cellular model, neurotransmitters

References

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