Enviar artigo por via de e-mail BIOLOGICAL ACTIVITY AND PROBABLE MECHANISMS OF ACTION OF DERIVATIVES OF TRYPTANTHRIN AND MOSTOTRIN ALKALOIDS
- Autores: Popov A.1, Degenkova L.2, Moskovkina T.3, Grammatikova N.2, Kuzmich A.1, Chernikov .1, Schekotichin A.2, Stonik A.1
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Afiliações:
- G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science
- Gauze Research Institute for The Search for New Antibiotics, Russian Academy of Sciences
- Institute of High Technologies and Advanced Materials, Far East Federal University
- Edição: Volume 508, Nº 1 (2023)
- Páginas: 53-57
- Seção: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135677
- DOI: https://doi.org/10.31857/S2686738922600807
- EDN: https://elibrary.ru/MTHALD
- ID: 135677
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Resumo
The alkaloid tryptanthrin and its water-soluble derivative mostotrin exhibit high antimicrobial and antitumor activity. To develop more active and less toxic preparations, syntheses and testing of the biological activities of a number of new and/or little-studied analogs were performed. Some of them have been shown to have higher cytotoxicity against tumor and antimicrobial cells than tryptanthrin and mostotrin. Thus, 8-fluorotryptanthrin effectively inhibits the proliferation of various tumor cell lines, namely: K-562/4, HCT-116 and HCT-116p53ko at lower concentrations than tryptanthrin, and 2,8-difluorostotrin exhibits a stronger antimicrobial effect against pathogenic bacteria S. aureus ATCC 29213 than mostotrin. It has been established that the antiproliferative properties of 8-fluorotryptanthrin and 8-fluormostotrin are associated with their ability in nanomolar concentrations to inhibit the cell cycle of tumor cells at the stage of transition from the G1 phase to the S phase. The data obtained indicate the prospects for further in-depth studies of their antitumor properties.
Sobre autores
A. Popov
G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science
Autor responsável pela correspondência
Email: popovam@piboc.dvo.ru
Russian Federation, Vladivostok
L. Degenkova
Gauze Research Institute for The Search for New Antibiotics, Russian Academy of Sciences
Email: popovam@piboc.dvo.ru
Russian Federation, Moscow
T. Moskovkina
Institute of High Technologies and Advanced Materials, Far East Federal University
Email: popovam@piboc.dvo.ru
Russian Federation, Vladivostok, Russian Island, Ayaks Bay, 10
N. Grammatikova
Gauze Research Institute for The Search for New Antibiotics, Russian Academy of Sciences
Email: popovam@piboc.dvo.ru
Russian Federation, Moscow
A. Kuzmich
G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science
Email: popovam@piboc.dvo.ru
Russian Federation, Vladivostok
O. Chernikov
G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science
Email: popovam@piboc.dvo.ru
Russian Federation, Vladivostok
A. Schekotichin
Gauze Research Institute for The Search for New Antibiotics, Russian Academy of Sciences
Email: popovam@piboc.dvo.ru
Russian Federation, Moscow
Academician Stonik
G.B. Elyakov Pacific Institute Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science
Email: popovam@piboc.dvo.ru
Russian Federation, Vladivostok
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