CHROMATIN REMODELING COMPLEX PBAF ACTIVATES AND REPRESSES INFLAMMATORY GENES
- Авторлар: Feoktistov A.1,2, Georgieva S.1, Soshnikova N.1,2
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Мекемелер:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Шығарылым: Том 513, № 1 (2023)
- Беттер: 590-594
- Бөлім: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/244397
- DOI: https://doi.org/10.31857/S2686738923600462
- EDN: https://elibrary.ru/GPQOZU
- ID: 244397
Дәйексөз келтіру
Аннотация
The PBAF chromatin remodeling complex regulates chromatin state and gene transcription in higher eukaryotes. In this work, we studied the role of PBAF in the regulation of NF–κB-and JAK/STAT-dependent activation of inflammatory genes. We performed knockdown of specific module subunit BAF200 resulted in destruction of the entire PBAF specific module and changed the level of the genes transcription of both pathways. PBAF can be both an activator and a repressor of inflammatory genes. Thus, PBAF is one of the important regulators of inflammatory gene expression.
Негізгі сөздер
Авторлар туралы
A. Feoktistov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: a.feo95@mail.ru
Russian Federation, Moscow; Russian Federation, Moscow
S. Georgieva
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: a.feo95@mail.ru
Russian Federation, Moscow
N. Soshnikova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: a.feo95@mail.ru
Russian Federation, Moscow; Russian Federation, Moscow
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