CHROMATIN REMODELING COMPLEX PBAF ACTIVATES AND REPRESSES INFLAMMATORY GENES

A. V. Feoktistov; Феоктистов А. В.; S. G. Georgieva; Георгиева С. Г.; N. V. Soshnikova; Сошникова Н. В.

doi:10.31857/S2686738923600462

CHROMATIN REMODELING COMPLEX PBAF ACTIVATES AND REPRESSES INFLAMMATORY GENES

Authors: Feoktistov A.V.¹^,2, Georgieva S.G.¹, Soshnikova N.V.¹^,2
Affiliations:
1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
2. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Issue: Vol 513, No 1 (2023)
Pages: 590-594
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/244397
DOI: https://doi.org/10.31857/S2686738923600462
EDN: https://elibrary.ru/GPQOZU
ID: 244397

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Abstract
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Abstract

The PBAF chromatin remodeling complex regulates chromatin state and gene transcription in higher eukaryotes. In this work, we studied the role of PBAF in the regulation of NF–κB-and JAK/STAT-dependent activation of inflammatory genes. We performed knockdown of specific module subunit BAF200 resulted in destruction of the entire PBAF specific module and changed the level of the genes transcription of both pathways. PBAF can be both an activator and a repressor of inflammatory genes. Thus, PBAF is one of the important regulators of inflammatory gene expression.

Keywords

SWI/SNF, eukaryotic transcription factors, inflammation, NF–kB, Jak/STAT, gene expression

References

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