INTRACELLULAR DELIVERY OF ANTIBODY-LIKE MOLECULE, CAPABLE TO INHIBIT C-MYC
- Авторлар: Lupanova T.1, Ulasov A.1, Khramtsov Y.1, Rozenkranz A.1,2, Georgiev G.1, Sobolev A.1,2
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Мекемелер:
- Institute of Gene Biology, RAS
- Lomonosov Moscow State University
- Шығарылым: Том 509, № 1 (2023)
- Беттер: 202-204
- Бөлім: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135666
- DOI: https://doi.org/10.31857/S2686738922600819
- EDN: https://elibrary.ru/LZEHSX
- ID: 135666
Дәйексөз келтіру
Аннотация
A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, an anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.
Негізгі сөздер
Авторлар туралы
T. Lupanova
Institute of Gene Biology, RAS
Хат алмасуға жауапты Автор.
Email: tatyanalupanova@yandex.ru
Russian, Moscow
A. Ulasov
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
Y. Khramtsov
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
A. Rozenkranz
Institute of Gene Biology, RAS; Lomonosov Moscow State University
Email: AlSobolev@yandex.ru
Russian, Moscow; Russian, Moscow
G. Georgiev
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
A. Sobolev
Institute of Gene Biology, RAS; Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: AlSobolev@yandex.ru
Russian, Moscow; Russian, Moscow
Әдебиет тізімі
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