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INTRACELLULAR DELIVERY OF ANTIBODY-LIKE MOLECULE, CAPABLE TO INHIBIT C-MYC
- Authors: Lupanova T.N.1, Ulasov A.V.1, Khramtsov Y.V.1, Rozenkranz A.A.1,2, Georgiev G.P.1, Sobolev A.S.1,2
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Affiliations:
- Institute of Gene Biology, RAS
- Lomonosov Moscow State University
- Issue: Vol 509, No 1 (2023)
- Pages: 202-204
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135666
- DOI: https://doi.org/10.31857/S2686738922600819
- EDN: https://elibrary.ru/LZEHSX
- ID: 135666
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Abstract
A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, an anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.
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About the authors
T. N. Lupanova
Institute of Gene Biology, RAS
Author for correspondence.
Email: tatyanalupanova@yandex.ru
Russian, Moscow
A. V. Ulasov
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
Y. V. Khramtsov
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
A. A. Rozenkranz
Institute of Gene Biology, RAS; Lomonosov Moscow State University
Email: AlSobolev@yandex.ru
Russian, Moscow; Russian, Moscow
G. P. Georgiev
Institute of Gene Biology, RAS
Email: AlSobolev@yandex.ru
Russian, Moscow
A. S. Sobolev
Institute of Gene Biology, RAS; Lomonosov Moscow State University
Author for correspondence.
Email: AlSobolev@yandex.ru
Russian, Moscow; Russian, Moscow
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