INTRACELLULAR DELIVERY OF ANTIBODY-LIKE MOLECULE, CAPABLE TO INHIBIT C-MYC

T. N. Lupanova; Лупанова Т. Н.; A. V. Ulasov; Уласов А. В.; Y. V. Khramtsov; Храмцов Ю. В.; A. A. Rozenkranz; Розенкранц А. А.; G. P. Georgiev; Георгиев Г. П.; A. S. Sobolev; Соболев А. С.

doi:10.31857/S2686738922600819

INTRACELLULAR DELIVERY OF ANTIBODY-LIKE MOLECULE, CAPABLE TO INHIBIT C-MYC

Authors: Lupanova T.N.¹, Ulasov A.V.¹, Khramtsov Y.V.¹, Rozenkranz A.A.¹^,2, Georgiev G.P.¹, Sobolev A.S.¹^,2
Affiliations:
1. Institute of Gene Biology, RAS
2. Lomonosov Moscow State University
Issue: Vol 509, No 1 (2023)
Pages: 202-204
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135666
DOI: https://doi.org/10.31857/S2686738922600819
EDN: https://elibrary.ru/LZEHSX
ID: 135666

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Abstract

A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, an anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.