TREX-2-ORC complex of D. melanogaster participates in nuclear export of histone MRNA
- Authors: Kurshakova M.M.1, Yakusheva Y.A.1, Georgieva S.G.1
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Affiliations:
- Engelhardt Institute of Molecular Biology RAS
- Issue: Vol 514, No 1 (2024)
- Pages: 44-49
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/258934
- DOI: https://doi.org/10.31857/S2686738924010089
- EDN: https://elibrary.ru/I KTUYXA
- ID: 258934
Cite item
Abstract
The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs: it associates with histone mRNPs, binds to histone H3 mRNA at the 3’-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm.
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About the authors
M. M. Kurshakova
Engelhardt Institute of Molecular Biology RAS
Author for correspondence.
Email: kursha@mail.ru
Russian Federation, Moscow
Y. A. Yakusheva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Russian Federation, Moscow
S. G. Georgieva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Academician of the RAS
Russian Federation, MoscowReferences
- Fischer T., Strasser K., Racz A., et al. // The EMBO journal. 2002. V. 21. № 21. P. 5843–5852.
- Rodríguez-Navarro S., Fischer T., Luo M. J., et al. // Cell. 2004. V. 116. № 1. P. 75–86.
- Jani D., Lutz S., Hurt E., et al. // Nucleic acids research. 2012. V. 40. № 10. P. 4562–4573.
- Jani D., Lutz S., Marshall N. J., et al. // Molecular cell. 2009. V. 33. № 6. P. 727–737.
- Ellisdon A. M., Dimitrova L., Hurt E. and Stewart M. // Nature structural & molecular biology. 2012. V. 19. № 3. P. 328–336.
- Dimitrova L., Valkov E., Aibara S., et al. // Structure. 2015. V. 23. № 7. P. 1246–1257.
- Jani D., Valkov E., Stewart M. // Nucleic acids research. 2014. V. 42. № 10. P. 6686–6697.
- Kurshakova M. M., Krasnov A. N., Kopytova D. V., et al. // The EMBO journal. 2007. V. 26. № 24. P. 4956–4965.
- Kopytova D., Popova Vol., Kurshakova M., et al. // Nucleic acids research. 2016. V. 44. № 10. P. 4920–4933.
- Bleichert F. // Current opinions in structural biology. 2019. V. 59. P. 195–204.
- Popova Vol., Brechalov A. // Nonreplicative functions of the origin recognition complex. 2018. V. 9. P. 460–473.
- Duronio R. J., Marzluff W. F. // RNA biology. 2017. V. 14. № 6. P. 726–738.
- Sun Y., Zhang Y., Aik W. S., et al. // Science. 2020b. V. 367. P. 700–703.
- Huang Y., Gattoni R., Stevenin J. and Steitz J. A. // Molecular Cell. 2003. V. 11. P. 837–843.
- Erkmann J. A., Sanchez R., Treichel N., et al. // RNA. 2005. V. 11. P. 45–58.
- Popova Vol.V., Georgieva S. G., Kopytova D. V. // Biochemistry and molecular biology journal. 2016. V. 2. P. 2–14.
- Куршакова М. М., Копытова Д. В., Георгиева С. Г. // Доклады АН. 2021. Т. 496. С. 66–69.
- Huang Y., Steitz J. A. // Molecular Cell. 2001. V. 7. P. 899–905.
- Fan J., Wang K., Du X., et al. // The EMBO Journal. 2019.
- Kopytova D. V., Orlova A. V., Krasnov A. N., et al. // Genes and Development. 2009. V. 24. P. 86–96.
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