TREX-2-ORC complex of D. melanogaster participates in nuclear export of histone MRNA
- Autores: Kurshakova M.1, Yakusheva Y.1, Georgieva S.1
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Afiliações:
- Engelhardt Institute of Molecular Biology RAS
- Edição: Volume 514, Nº 1 (2024)
- Páginas: 44-49
- Seção: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/258934
- DOI: https://doi.org/10.31857/S2686738924010089
- EDN: https://elibrary.ru/I KTUYXA
- ID: 258934
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Resumo
The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs: it associates with histone mRNPs, binds to histone H3 mRNA at the 3’-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm.
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Sobre autores
M. Kurshakova
Engelhardt Institute of Molecular Biology RAS
Autor responsável pela correspondência
Email: kursha@mail.ru
Rússia, Moscow
Y. Yakusheva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Rússia, Moscow
S. Georgieva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Academician of the RAS
Rússia, MoscowBibliografia
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