TREX-2-ORC complex of D. melanogaster participates in nuclear export of histone MRNA
- Авторлар: Kurshakova M.1, Yakusheva Y.1, Georgieva S.1
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Мекемелер:
- Engelhardt Institute of Molecular Biology RAS
- Шығарылым: Том 514, № 1 (2024)
- Беттер: 44-49
- Бөлім: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/258934
- DOI: https://doi.org/10.31857/S2686738924010089
- EDN: https://elibrary.ru/I KTUYXA
- ID: 258934
Дәйексөз келтіру
Аннотация
The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs: it associates with histone mRNPs, binds to histone H3 mRNA at the 3’-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm.
Негізгі сөздер
Толық мәтін
Авторлар туралы
M. Kurshakova
Engelhardt Institute of Molecular Biology RAS
Хат алмасуға жауапты Автор.
Email: kursha@mail.ru
Ресей, Moscow
Y. Yakusheva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Ресей, Moscow
S. Georgieva
Engelhardt Institute of Molecular Biology RAS
Email: kursha@mail.ru
Academician of the RAS
Ресей, MoscowӘдебиет тізімі
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