Email this article STIMULATION OF OVULATION IN IMMATURE FEMALE RATS USING ORTHOSTERIC AND ALLOSTERIC LUTEINIZING HORMONE RECEPTOR AGONISTS
- Authors: Fokina E.A.1, Derkach K.V.1, Bakhtuykov A.A.1, Sorokoumov V.N.2, Lebedev I.A.1, Morina I.Y.1, Shpakov A.O.1
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Affiliations:
- Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- Institute of Chemistry, St. Petersburg State University
- Issue: Vol 508, No 1 (2023)
- Pages: 30-34
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135668
- DOI: https://doi.org/10.31857/S2686738922700032
- EDN: https://elibrary.ru/MUDQQJ
- ID: 135668
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Abstract
Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) are widely used for the treatment of reproductive disorders and for controlled ovulation induction, but their use is limited by side effects. Allosteric agonists of the LH/hCG receptor, including thieno[2,3-d]thienopyrimidine TP03 developed by us, can become an alternative. TP03 (50 mg/rat, i.p.) when administered to immature female rats treated 48 hours before with Follimag has been shown to increase progesterone levels (maximum 8 hours post-treatment) and induce ovulation, as indicated by the appearance at 24 hours corpus luteum (8.6 ± 0.5 per ovary). In terms of its activity, TP03 is comparable to hCG, although it acts more moderately. In the ovaries, unlike hCG, TP03 does not lead to an increase in the expression of vascular endothelial growth factor, which can cause ovarian hyperstimulation syndrome. Thus, TP03 is a promising drug as an ovulation inducer and ovarian steroidogenesis stimulator.
About the authors
E. A. Fokina
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
K. V. Derkach
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
A. A. Bakhtuykov
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
V. N. Sorokoumov
Institute of Chemistry, St. Petersburg State University
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
I. A. Lebedev
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
I. Yu. Morina
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
A. O. Shpakov
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Author for correspondence.
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
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