CLINICAL AND IMMUNOLOGICAL FEATURES IN ACUTE RESPIRATORY-VIRAL INFECTIONS IN CHILDREN WITH BRONCHIAL ASTHMA

Aim. To study the immune status during acute respiratory viral infections (ARVI) in children with bronchial asthma (AD). Materials and methods. We examined 96 children aged 3 to 7 years during the development of ARVI. At the same time, 62 children (the main group) suffered from AD, 34 - did not have a history of allergy and constituted a comparison group. The control group included 20 healthy children of a similar age. The levels of interferons a and g, interleukins (IL)-4, IL-5, IL-13, CD3+, CD4+, CD8+, CD22+, immunoglobulins (Ig) A, M, G, E were determined in all patients. Results. It was found that acute respiratory viral infections in children with AD are characterized by a complicated and torpid course, an increase in the duration of the main syndromes and the overall duration of the disease (in the main group 15.47±0.56 days, in the comparison group - 9.35±0.74 days; p<0.001). The immune status of children with AD during ARVI is characterized by a significant (p<0.05) lower relative content of T lymphocytes (CD3+) in the blood, an increase in the level of total IgE and a decrease in the concentration of serum IgA in all periods of ARVI. Conclusion. The immune status of children with AD during the period of acute respiratory viral infections is characterized by inhibition of both cellular and humoral immunity, which persists at the time of clinical recovery.

acute respiratory infection, bronchial asthma, children, cough, immunity