Trace elements and metalloenzymes in patients with acute pancreatitis
- Authors: Kotchergin V.G.1,2, Sviridov S.V.1, Subbotin V.V.2, Vetsheva M.S.3
-
Affiliations:
- The Russian National Research Medical University named after N.I. Pirogov
- Moscow Clinical Scientific Center
- The First Sechenov Moscow State Medical University (Sechenov University)
- Issue: Vol 2, No 3 (2021)
- Pages: 141-156
- Section: Reviews
- URL: https://journals.rcsi.science/2658-4433/article/view/99881
- DOI: https://doi.org/10.17816/clinutr99881
- ID: 99881
Cite item
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Abstract
For many decades, acute pancreatitis has occupied third place in the structure of emergency surgical abdominal conditions, second to acute calculous cholecystitis and acute appendicitis. Simultaneously, acute pancreatitis ranks first in mortality among other acute surgical conditions. Often acute pancreatitis occurs under the “mask” of gastroenterological problems.
Complex electrolyte and trace element disorders are often formed in the early stages of developing pancreatitis. The concepts of diagnosis and therapeutic and surgical treatment of acute pancreatitis are formulated and reflected in numerous domestic and international monographs and recommendations, which emphasize the important role of water-electrolyte disorders, microbiota, systemic inflammatory response, and cytokine storm as etiological factors in inflammatory development and maintenance and destructive pancreatic and parapancreatic cellular processes. Sepsis, septic shock, and multiple organ failure are the leading causes of mortality in patients with infected pancreatic necrosis.
Problems of the interrelation and role of individual trace elements and metalloenzymes as etiological factors in acute pancreatitis formation, prognostic biochemical markers of the severity of patients’ condition, and prognostic criteria of mortality and recovery are actively studied.
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##article.viewOnOriginalSite##About the authors
Vladimir G. Kotchergin
The Russian National Research Medical University named after N.I. Pirogov; Moscow Clinical Scientific Center
Author for correspondence.
Email: asqwerty1@yandex.ru
ORCID iD: 0000-0002-4995-1048
SPIN-code: 8520-0376
MD
Russian Federation, Moscow; 86, Shosse Entuziastov, Moscow, 111123Sergey V. Sviridov
The Russian National Research Medical University named after N.I. Pirogov
Email: sergey.sviridov.59@mail.ru
ORCID iD: 0000-0002-9976-8903
SPIN-code: 4974-9195
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowValerii V. Subbotin
Moscow Clinical Scientific Center
Email: asfold@mail.ru
ORCID iD: 0000-0002-0921-7199
SPIN-code: 4089-9559
MD, Dr. Sci. (Med.)
Russian Federation, 86, Shosse Entuziastov, Moscow, 111123Maria S. Vetsheva
The First Sechenov Moscow State Medical University (Sechenov University)
Email: vetsheva_m_s@staff.sechenov.ru
ORCID iD: 0000-0002-2180-6324
SPIN-code: 5901-8956
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowReferences
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