Email this article Vitamin status of patients with certain chronic non-communicable diseases
- Authors: Sharafetdinov K.K.1,2,3, Kodentsova V.M.1, Vrzhesinskaya O.A.1, Kosheleva O.V.1, Beketova N.A.1, Leonenko S.N.1, Plotnikova O.A.1, Pilipenko P.4, Gapparova K.M.1, Pilipenko V.I.1, Derbeneva S.A.1
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Affiliations:
- Federal Research Center for Nutrition and Biotechnology
- Russian Medical Academy of Continuing Professional Education
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Federal State Budgetary Institution of Science “Federal Research Center for Nutrition and Biotechnology”
- Issue: Vol 1, No 3 (2020)
- Pages: 105-116
- Section: Original Study Articles
- URL: https://journals.rcsi.science/2658-4433/article/view/50303
- DOI: https://doi.org/10.17816/clinutr50303
- ID: 50303
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Abstract
Background. Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression. Data on the actual vitamin status of patients are necessary to develop measures for its improvement.
Aim. To characterize the supply of persons with non-communicable diseases with vitamins A, E, C, B2 and β-carotene by determining their level in the blood of patients.
Material and methods. The blood serum level of vitamins C, A, E, B2 and β-carotene in 138 patients (41 men and 97 women) 22–80 years old with cardiovascular diseases, obesity, gastrointestinal diseases, type 2 diabetes mellitus (T2DM), osteoarthrosis has been determined.
Results. Vitamin C concentration corresponded to adequate status in approximately 2/3 of the examined patients; among patients with T2DM, such sufficiency occurred 1.6–1.9 fold less often than in other groups. The frequency of reduced levels of vitamins C, A and E was statistically significantly more frequent in patients with gastrointestinal diseases. The γ-/α-tocopherol ratio in the serum of patients in all groups was close to 1:50, while in patients with gastrointestinal diseases reached 1:60.7. The proportion of patients sufficiently supplied with all studied vitamins ranged from 15.8 to 70.0%. Patients with osteoarthrosis were best of all provided with all vitamins: multiple (3 or more vitamins) vitamin deficiency was not found. In other groups of patients, multiple vitamin deficiency occurred in 5.3–27.6% of the examined (an average of 16.4%). Among patients with gastrointestinal diseases there was not a single person sufficiently provided with all the studied vitamins. Multiple vitamin deficiency in patients with gastrointestinal diseases was detected more often (p <0.01) compared with patients with T2DM and osteoarthrosis. Given the high prevalence of vitamin D deficiency, it is possible to extrapolate that a significant proportion of patients with a combined deficiency of 2 vitamins (6.9–31.6% in the samples examined) will move into the category of persons with a simultaneous deficiency of 3 vitamins.
Conclusion. The purposeful development of supplements containing effective doses of vitamins for various nosologies is necessary.
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##article.viewOnOriginalSite##About the authors
Khaider Kh. Sharafetdinov
Federal Research Center for Nutrition and Biotechnology; Russian Medical Academy of Continuing Professional Education; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: sharafandr@mail.ru
SPIN-code: 1236-8210
MD, PhD, Professor
Russian Federation, Ustinskiy proezd, 109240, Moscow, Russia; Moscow; MoscowVera M. Kodentsova
Federal Research Center for Nutrition and Biotechnology
Email: kodentsova@ion.ru
ORCID iD: 0000-0002-5288-1132
MD, PhD, Professor
Russian Federation, MoscowOksana A. Vrzhesinskaya
Federal Research Center for Nutrition and Biotechnology
Email: vr.oksana@yandex.ru
ORCID iD: 0000-0002-8973-8153
MD, PhD
Russian Federation, MoscowOlga V. Kosheleva
Federal Research Center for Nutrition and Biotechnology
Email: kosheleva@ion.ru
ORCID iD: 0000-0003-2391-9880
MD
Russian Federation, MoscowNina A. Beketova
Federal Research Center for Nutrition and Biotechnology
Email: beketova@ion.ru
ORCID iD: 0000-0003-2810-2351
MD, PhD
Russian Federation, MoscowSvetlana N. Leonenko
Federal Research Center for Nutrition and Biotechnology
Email: svetlanaleonenko6@gmail.com
ORCID iD: 0000-0003-0048-4220
MD
Russian Federation, MoscowOxana A. Plotnikova
Federal Research Center for Nutrition and Biotechnology
Email: plot_oks@mail.ru
ORCID iD: 0000-0001-6061-0095
MD, PhD
Russian Federation, MoscowPilipenko Pilipenko
Federal State Budgetary Institution of Science “Federal Research Center for Nutrition and Biotechnology”
Email: kushonok9@gmail.com
ORCID iD: 0000-0002-0628-0854
SPIN-code: 4388-9613
MD, PhD; address: 2/14, Ustinskiy proezd, 109240, Moscow, Russia
Russian Federation, MoscowKamilat M. Gapparova
Federal Research Center for Nutrition and Biotechnology
Email: kgapparova@mail.ru
ORCID iD: 0000-0003-1223-8545
MD, PhD
Russian Federation, MoscowVladimir I. Pilipenko
Federal Research Center for Nutrition and Biotechnology
Email: pilipenkowork@rambler.ru
ORCID iD: 0000-0001-5632-1880
MD, PhD
Russian Federation, MoscowSvetlana A. Derbeneva
Federal Research Center for Nutrition and Biotechnology
Email: sderbeneva@yandex.ru
ORCID iD: 0000-0003-1876-1230
MD, PhD
Russian Federation, MoscowReferences
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