Toxicological characteristics of the drug Hyperico
- 作者: Sklyarov O.1, Rakhmatullin E.2, Babicheva O.1, Litvinov N.1
-
隶属关系:
- Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
- Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological Safety”
- 期: 编号 4 (2024)
- 页面: 99-101
- 栏目: Zootechnics
- URL: https://journals.rcsi.science/2500-2082/article/view/262861
- DOI: https://doi.org/10.31857/S2500208224040199
- EDN: https://elibrary.ru/xjqztb
- ID: 262861
如何引用文章
详细
The article presents the results of a study of the toxicity of the drug Hyperico. It has been established that the drug is low-toxic and safe for animals with daily use. It does not provoke the development of pathological reactions. According to the classification of Hodge and Sterner (1943), Hyperico can be classified as toxicity class 6 – relatively harmless. The LD50 value of the drug after intragastric administration to white rats was ≥ 36400 mg/kg, to mice – ≥ 45400 mg/kg, irritation of the mucous membranes of the digestive tract was not observed. According to GOST 12.1.007.76, Hyperico belongs to the 4th hazard rating, that is low-hazard substances. Based on the results of the study, a reasonable conclusion can be made that Hyperico does not have a toxic effect on calves. There are no contraindications for conducting clinical trials of the drug Hyperico.
全文:
作者简介
O. Sklyarov
Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
编辑信件的主要联系方式.
Email: scliarov@yandex.ru
Grand PhD in Veterinary Sciences
俄罗斯联邦, MoscowE. Rakhmatullin
Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological Safety”
Email: scliarov@yandex.ru
Grand PhD in Veterinary Sciences
俄罗斯联邦, KazanO. Babicheva
Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
Email: scliarov@yandex.ru
Leading Researcher
俄罗斯联邦, MoscowN. Litvinov
Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
Email: scliarov@yandex.ru
Leading Specialist
俄罗斯联邦, Moscow参考
- Berezovskaya I.V. Klassifikaciya himicheskih veshchestv po parametram ostroj toksichnosti pri parenteral’nyh sposobah vvedeniya // Himiko-farmacevticheskij zhurnal. 2003. T. 37. № 3. S. 32–34.
- Vahrusheva T.I. Analiz zabolevaemosti molodnyaka krupnogo skota vnutrennimi nezaraznymi patologiyami v AO PZ «Krasnoturanskij» Krasnoyarskogo kraya // V sb. Vseros. nauch. konf. g. Novosibirsk: IC INGAU «Zolotoj Kolos», 2019. S. 194–197.
- GOST 12.1.007-76. Mezhgosudarstvennyj standart. Sistema standartov bezopasnosti truda. Vrednye veshchestva. Klassifikaciya i obshchie trebovaniya bezopasnosti. Data vvedeniya 01.01.1977.
- GOST 33216-2014 «Rukovodstvo po soderzhaniyu i uhodu za laboratornymi zhivotnymi»
- Kondrahin I.P., Talanov G.A., Pak V.V. Vnutrennie nezaraznye bolezni zhivotnyh. M.: KolosS, 2003. 461 s.
- Pavlov D.K. Zabolevaniya zheludochno-kishechnogo trakta u novorozhdennyh telyat // Veterinarnaya zhizn’. 2006. № 11. S. 12–14.
- Rahmatullin E.K., Sklyarov O.D. Preparat dlya lecheniya i profilaktiki ostryh zheludochno-kishechnyh boleznej novorozhdennyh telyat. Patent na izobretenie 2740602 C1, 15.01.2021. Zayavka № 2020107209 ot 17.02.2020.
- Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv. Chast’ pervaya. Pod obshchej redakciej doktora medicinskih nauk A.N. Mironova. M.: Grif i K, 2012. 944 s.
- Smolencev S.Yu. Metody lecheniya rasstrojstva pishchevareniya telyat (obzor) // Vestnik Marijskogo gosudarstvennogo universiteta. Seriya “Sel’skohozyajstvennye nauki. Ekonomicheskie nauki”. 2022. T. 8. № 3. S. 280–287. https://doi.org/10.30914/2411-9687-2022-8-3-280-287
- Habriev R.U. Rukovodstvo po eksperimental’nomu i doklinicheskomu izucheniyu novyh farmakologicheskih veshchestv. 2-e izd., pererab. i dop. M.: OAO “Izdatel’stvo ‘Medicina’”, 2005. 832 s.
- Hodge H.C., Gosselin R.E., Smith R.P., Gleason M.N. Clinical Toxicology of Commercial Products // Acute Poisoning. 4th ed., Williams & Wilkins, Baltimore. 1975. 427 p.