Email this article New prognostic method for estimation of lipid distress syndrome development in patients with chronic hepatitis C
- Authors: Konstantinov D.Y.1, Nedugov G.V.2, Popova L.L.1, Konstantinova E.A.1
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Affiliations:
- Samara State Medical University
- Samara Regional Bureau of Forensic Medical Expertise
- Issue: Vol 4, No 1 (2019)
- Pages: 16-19
- Section: Infectious diseases
- URL: https://journals.rcsi.science/2500-1388/article/view/43735
- DOI: https://doi.org/10.35693/2500-1388-2019-4-1-16-19
- ID: 43735
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Abstract
Objectives – to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C.
Material and methods. We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years.
Results. Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Cross-checking of prediction accuracy was carried out on the data of examination of other 100 patients.
Conclusion. The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.
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##article.viewOnOriginalSite##About the authors
Dmitrii Yur'evich Konstantinov
Samara State Medical University
Author for correspondence.
Email: dk.samgmu@mail.ru
ORCID iD: 0000-0002-6177-8487
PhD, Associate Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU
Russian Federation, SamaraGerman V. Nedugov
Samara Regional Bureau of Forensic Medical Expertise
Email: nedugovh@mail.ru
ORCID iD: 0000-0002-7380-3766
PhD, Head of the Forensic Histology Department of Samara Regional Bureau of Forensic Medical Expertise
Russian Federation, SamaraLarisa L. Popova
Samara State Medical University
Email: infect.samgmu@mail.ru
PhD, Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU
Russian Federation, SamaraElena A. Konstantinova
Samara State Medical University
Email: a.konstanta@mail.ru
ORCID iD: 0000-0002-6022-0983
PhD, Associate Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU
Russian Federation, SamaraReferences
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- Савельев В.С., Петухов В.А. Липидный дистресс-синдром. М., 2010. [Savel'ev VS, Petukhov VA. Lipidnyi distress-sindrom. Мoscow, 2010. (In Russ.)].
- Константинов Д.Ю., Недугов Г.В., Суздальцев А.А., Константинова Е.А. Прогнозирование развития липидного дистресс-синдрома при хроническом вирусном гепатите С. Инфекционные болезни. 2018;16(4):34–37. [Konstantinov DYu, Nedugov GV, Suzdaltsev AA, Konstantinova EA. Prognosis of the development of lipid distress syndrome in chronic viral hepatitis C. Infektsionnye bolezni. 2018;16(4):34–37. (In Russ.)]. doi: 10.20953/1729-9225-2018-4-34-37
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