Email this article Assessment of naphazoline effect on erythrocyte superoxide dismutase activity in rats under experimental modeling of acute radiation sickness
- Authors: Ivanov V.S.1, Seleznev A.B.2, Raguzin E.V.2, Ivchenko E.V.1, Pechurina T.B.2, Ivanov I.M.2, Glushenko D.D.1, Glushakov R.V.1
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Affiliations:
- Military Medical Academy named after S.M. Kirov
- State Research Scientific Institute of Military Medicine
- Issue: Vol 8, No 1 (2023)
- Pages: 60-65
- Section: Pharmacology
- URL: https://journals.rcsi.science/2500-1388/article/view/131502
- DOI: https://doi.org/10.35693/2500-1388-2023-8-1-60-65
- ID: 131502
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Abstract
Aim – to assess the activity of superoxide dismutase in erythrocytes of rats after a single intramuscular injection of naphazoline in radiofrequency dose and in experimental simulation of acute radiation sickness.
Material and methods. The activity of erythrocytes superoxide dismutase (SOD) after single intramuscular injection of nafazoline in experimental modeling of acute radiation sickness was investigated. The pharmacological properties and mechanisms of radioprotective action of nafazoline were clarified based on the dynamics of activity of erythrocytes SOD in intact and irradiated animals with the dose of 7,4 Gy.
Results. The superoxide dismutase activity was found to increase significantly 60 min after single intramuscular administration of nafazolin at a dose of 5 mg/kg. Under experimental conditions of acute radiation disease modeling, a decrease in superoxide dismutase activity was observed within the first hour after exposure, evidencing the direct involvement of the antioxidant system components in the inactivation of free-radical reaction products.
Conclusion. The radioprotective properties of naphazoline may be due not only to reduction of oxygen delivery to the cells of radiosensitive tissues and inhibition of their metabolism by effect on α2-adreno- and imidazoline receptors, but also by activation of antioxidant system links.
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##article.viewOnOriginalSite##About the authors
Valerii S. Ivanov
Military Medical Academy named after S.M. Kirov
Email: ivanovmed84@mail.ru
ORCID iD: 0000-0002-2643-7767
Senior Resident of the Clinic of Naval Therapy
Russian Federation, Saint-PetersburgAleksei B. Seleznev
State Research Scientific Institute of Military Medicine
Email: alexseleznov@list.ru
ORCID iD: 0000-0002-9278-5698
PhD, Associate Professor, Deputy Head of Research Test Center of Medical and Biological Defense
Russian Federation, Saint-PetersburgEvgenii V. Raguzin
State Research Scientific Institute of Military Medicine
Email: evgeny.raguzin@yandex.ru
ORCID iD: 0000-0002-1707-6912
PhD, Deputy Head of Scientific-Research Testing Department
Russian Federation, Saint-PetersburgEvgenii V. Ivchenko
Military Medical Academy named after S.M. Kirov
Email: 8333535@mail.ru
ORCID iD: 0000-0001-5582-1111
PhD, Associate Professor, Deputy Head of the Military Medical Academy for Scientific Work
Russian Federation, Saint-PetersburgTatyana B. Pechurina
State Research Scientific Institute of Military Medicine
Email: tat79@list.ru
ORCID iD: 0000-0002-8228-2800
PhD, Junior Researcher
Russian Federation, Saint-PetersburgIgor M. Ivanov
State Research Scientific Institute of Military Medicine
Email: igor611ivanov@gmail.com
ORCID iD: 0000-0002-8708-8484
PhD, Head of Research and Development Testing Department
Russian Federation, Saint-PetersburgDaniil D. Glushenko
Military Medical Academy named after S.M. Kirov
Author for correspondence.
Email: glushenko.daniil.d@yandex.ru
ORCID iD: 0000-0001-9425-6565
5th year cadet, 3rd Faculty
Russian Federation, Saint-PetersburgRuslan V. Glushakov
Military Medical Academy named after S.M. Kirov
Email: glushakovruslan@gmail.com
ORCID iD: 0000-0002-0161-5977
PhD, Associate Professor, Head of Research Department (Medical and Biological Research) of Research Center
Russian Federation, Saint-PetersburgReferences
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