Email this article Biological activity of new 6-[(1-naphthylmethyl)thio)]-4-chloropyrazolo[3,4-d]pyrimidines
- Authors: Ofitserova E.S.1, Alekseeva L.N.1, Shklyarenko A.A.1, Yakovlev I.P.1
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Affiliations:
- Saint Petersburg State Chemical and Pharmaceutical University
- Issue: Vol 20, No 1-2 (2020)
- Pages: 146-151
- Section: Pharmacy
- URL: https://journals.rcsi.science/2410-3764/article/view/54533
- DOI: https://doi.org/10.17816/2072-2354.2020.20.1.146-151
- ID: 54533
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Abstract
Topicality. This article presents the results of the study of the biological activity of newly synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines. The acute toxicity of 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines was determined experimentally on non-linear white male mice with a total weight of 16–20 g. A generation model was used to experimentally evaluate the analgesic activity acetic “writhing” in male mice. It was experimentally confirmed that the new synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines were non-toxic and had pronounced analgesic activity.
Aim: to study the biological activity of the new synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines.
Materials and methods. The prediction of the likely types of biological activity was carried out with the use of PASS computer program. The acute toxicity of 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines was determined experimentally on non-linear white male mice. Analgesic activity was established on a model of acetic acid “writhing” in mice.
Results. 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines were classified as non-toxic substances (LD50 — 2000 mg / kg). The analgesic activity of the test compounds was higher than that of the reference drug.
Conclusion. The new synthesized 6-[(1-naphthylmethyl]thio)-4-chloropyrazolo[3,4-d]pyrimidines are non-toxic and have pronounced analgesic activity.
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##article.viewOnOriginalSite##About the authors
Ekaterina S. Ofitserova
Saint Petersburg State Chemical and Pharmaceutical University
Author for correspondence.
Email: OfizerovaES@mail.ru
Postgraduate student, Department of Organic Chemistry
Russian Federation, Saint PetersburgLilia N. Alekseeva
Saint Petersburg State Chemical and Pharmaceutical University
Email: lilia.ovsyannikova@pharminnotech.com
Candidate of Pharmaceutical Sciences
Russian Federation, Saint PetersburgArtem A. Shklyarenko
Saint Petersburg State Chemical and Pharmaceutical University
Email: tjema@yandex.ru
Postgraduate student, Department of Organic Chemistry
Russian Federation, Saint PetersburgIgor P. Yakovlev
Saint Petersburg State Chemical and Pharmaceutical University
Email: nauka@spcpa.ru
Doctor of Chemical Sciences, Professor
Russian Federation, Saint PetersburgReferences
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