Email this article The antioxidant therapy of toxicity induced by transplantable carcinoma and irradiation
- Authors: Skopin PI1
-
Affiliations:
- Мордовский государственный университет им. Н.П. Огарева
- Issue: Vol 10, No 3-4 (2010)
- Pages: 236-239
- Section: Articles
- URL: https://journals.rcsi.science/2410-3764/article/view/25133
- DOI: https://doi.org/10.17816/2072-2354.2010.0.3-4.236-239
- ID: 25133
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Abstract
The objective of the study was the investigation of the status of oxidative damage in rats with transplantable cholangiocellular RS-1 carcinoma. We investigated the ability of derivative LBK-149 oxinicotinic acid to control oxidative damage induced by tumor and irradiation. LBK-149 at a dose of 100 mg/kg was injected i.p. or i.m. before or after irradiation. Biochemical methods were used for this investigation. The greatest therapeutic efficiency has noted been at a combination LBK-149 after irradiation, in comparison with monoirradiation and preventive injection of a LBK-149. It was shown that injection LBK-149 (100 mg/kg) in 10 day after irradiation has allowed to increase a doze of irradiation up to 5 Gy without increase of level of oxidative damage.
About the authors
P I Skopin
Мордовский государственный университет им. Н.П. Огарева
Email: skopinpi@mail.ru
старший преподаватель кафедры онкологии с курсом лучевой диагностики и лучевой терапии; Мордовский государственный университет им. Н.П. Огарева
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