The effect of vascular peptide bioregulator on microcirculation in the brain cortex of old rats
- Autores: Sokolova I.1, Sergeev I.1, Ryzhak G.2, Khavinson V.1,2
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Afiliações:
- Pavlov Institute of Physiology
- St. Petersburg Institute of Bioregulation and Gerontology
- Edição: Volume 6, Nº 4 (2016)
- Páginas: 328-332
- Seção: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205129
- DOI: https://doi.org/10.1134/S2079057016040135
- ID: 205129
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Resumo
At a video facility for the study of intravital brain microcirculation, we found that, after a course treatment with vascular peptide bioregulator, the microvasculature density of the pial tunic in old (22–24 months) rats increased by about 2.5–2.8 times; the constriction and dilative reactions of the pial arterioles increased after the application of noradrenaline and acetylcholine onto the brain surface, respectively. However, perfusion into brain tissues did not increase, but the degree of oxygen saturation in microvessels of this tissue region increased.
Sobre autores
I. Sokolova
Pavlov Institute of Physiology
Autor responsável pela correspondência
Email: sib@kolt.infran.ru
Rússia, St. Petersburg, 199034
I. Sergeev
Pavlov Institute of Physiology
Email: sib@kolt.infran.ru
Rússia, St. Petersburg, 199034
G. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Rússia, St. Petersburg, 197110
V. Khavinson
Pavlov Institute of Physiology; St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Rússia, St. Petersburg, 199034; St. Petersburg, 197110