The effect of vascular peptide bioregulator on microcirculation in the brain cortex of old rats
- Authors: Sokolova I.B.1, Sergeev I.V.1, Ryzhak G.A.2, Khavinson V.K.1,2
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Affiliations:
- Pavlov Institute of Physiology
- St. Petersburg Institute of Bioregulation and Gerontology
- Issue: Vol 6, No 4 (2016)
- Pages: 328-332
- Section: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205129
- DOI: https://doi.org/10.1134/S2079057016040135
- ID: 205129
Cite item
Abstract
At a video facility for the study of intravital brain microcirculation, we found that, after a course treatment with vascular peptide bioregulator, the microvasculature density of the pial tunic in old (22–24 months) rats increased by about 2.5–2.8 times; the constriction and dilative reactions of the pial arterioles increased after the application of noradrenaline and acetylcholine onto the brain surface, respectively. However, perfusion into brain tissues did not increase, but the degree of oxygen saturation in microvessels of this tissue region increased.
About the authors
I. B. Sokolova
Pavlov Institute of Physiology
Author for correspondence.
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg, 199034
I. V. Sergeev
Pavlov Institute of Physiology
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg, 199034
G. A. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg, 197110
V. Kh. Khavinson
Pavlov Institute of Physiology; St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 197110