Age-related changes in microcirculation in the cortex of hypertonic rats

I. B. Sokolova; I. V. Sergeev; O. R. Fedotova; N. N. Melnikova; D. P. Dvoretsky

doi:10.1134/S2079057017010143

Age-related changes in microcirculation in the cortex of hypertonic rats

Authors: Sokolova I.B.¹, Sergeev I.V.¹, Fedotova O.R.², Melnikova N.N.¹, Dvoretsky D.P.¹
Affiliations:
1. I.P. Pavlov Institute of Physiology
2. Research Institute of Experimental Medicine, Northwest Branch
Issue: Vol 7, No 1 (2017)
Pages: 51-55
Section: Article
URL: https://journals.rcsi.science/2079-0570/article/view/205516
DOI: https://doi.org/10.1134/S2079057017010143
ID: 205516

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Abstract

We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.