Optimization of reparative osteogenesis in the jaw in aging (preclinical studies)

Abstract

The article discusses the results of preclinical tests of the possibility to optimize reparative osteogenesis in postoperative bone cavities of jaws in old rats by the application of Kartalaks, a peptide bioregulator. According to histological and morphometric assessments, the use of Kartalaks has a positive effect on the course of reparative osteogenesis in the mandible of old rats. Reparative osteogenesis of a standard defect in the mandible has been shown to occur in old animals at early stages (within 30 days), as in to the control group, if the application of Kartalaks in old animals was started 30 days before the planned surgical intervention. The formation of regenerated complex tissue containing a smaller proportion of connective and cartilage tissues, which is also characterized by a more advanced remodeling processes in the newly formed bone tissue, was observed on the 60th–120th day after the start of the experiment in the test variation with preliminary application of the peptide bioregulator (Kartalaks) as compared with the control group and the group of animals beginning administration on the day of surgery completion.