What can be an alternative to non-steroidal anti-inflammatory drugs for the control of acute musculoskeletal pain in a patient with a history of myocardial infarction and gastrointestinal bleeding?

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Abstract

Fast and most complete pain relief is the most important problem in the treatment of patients with non-specific back pain, osteoarthritis and rheumatic pathology of periarticular soft tissues. The modern concept of analgesic therapy involves anintegrated approach to the use of drugs and treatments that affect the various links in the pathogenesis of pain. It means, that the first here are the non-steroidal anti- inflammatory drugs (NSAIDs). However, NSAIDs can cause dangerous complications, so their use is severely restricted with serious comorbid diseases of the gastrointestinal tract and is contraindicated at high cardiovascular risk - for example, in patients with symptomatic ischemic heart disease, myocardial infarction and stroke. This review discusses analgesics that may be a safer alternative to NSAIDs in this situation. Such preparation may be considered as flupirtine, an analgesic drug with an original mechanism of action, has proven its effectiveness and safety compared with NSAIDs and opioids in a series of well-designed clinical trials.

About the authors

A. E Karateev

V.A.Nasonova Research Institute of Rheumatology

Email: aekarateev@rambler.ru
д-р мед. наук, ФГБНУ НИИ ревматологии им. В.А.Насоновой 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34A

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