Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions
- 作者: Bozo I.1,2,3,4, Deev R.1,4,5, Zhuravlyova M.6, Komlev V.4,7, Popov V.4, Smirnov I.7, Fedotov A.7
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隶属关系:
- Human Stem Cells Institute
- Moscow State University of Medicine and Dentistry
- State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Federal Research Center Crystallography and Photonics
- Ryazan State Medical University
- Kazan (Volga Region) Federal University
- Baikov Institute of Metallurgy and Materials Science
- 期: 卷 9, 编号 1 (2018)
- 页面: 70-74
- 栏目: Article
- URL: https://journals.rcsi.science/2075-1133/article/view/207116
- DOI: https://doi.org/10.1134/S2075113318010045
- ID: 207116
如何引用文章
详细
This work is aimed at the optimization of the phase composition, surface morphology, and microstructure of matrices based on octacalcium phosphate (OCP) in order to increase the maximum dose and dosing accuracy of immobilized nucleic acids (NAs). It is determined that the modification of the scaffold with magnesium leads to a 1.4-fold increase in binding of plasmid DNA, which can further be used for the fabrication of medical products with the specified high concentration of biologically active NAs. Preliminary in vitro evaluation shows that the addition of magnesium to OCP regulates metabolic activity of HEK-293FT cell lines.
作者简介
I. Bozo
Human Stem Cells Institute; Moscow State University of Medicine and Dentistry; State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal Research Center Crystallography and Photonics
Email: komlev@mail.ru
俄罗斯联邦, Moscow; Moscow; Moscow; Moscow
R. Deev
Human Stem Cells Institute; Federal Research Center Crystallography and Photonics; Ryazan State Medical University
Email: komlev@mail.ru
俄罗斯联邦, Moscow; Moscow; Ryazan
M. Zhuravlyova
Kazan (Volga Region) Federal University
Email: komlev@mail.ru
俄罗斯联邦, Kazan
V. Komlev
Federal Research Center Crystallography and Photonics; Baikov Institute of Metallurgy and Materials Science
编辑信件的主要联系方式.
Email: komlev@mail.ru
俄罗斯联邦, Moscow; Moscow
V. Popov
Federal Research Center Crystallography and Photonics
Email: komlev@mail.ru
俄罗斯联邦, Moscow
I. Smirnov
Baikov Institute of Metallurgy and Materials Science
Email: komlev@mail.ru
俄罗斯联邦, Moscow
A. Fedotov
Baikov Institute of Metallurgy and Materials Science
Email: komlev@mail.ru
俄罗斯联邦, Moscow