Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions
- Autores: Bozo I.1,2,3,4, Deev R.1,4,5, Zhuravlyova M.6, Komlev V.4,7, Popov V.4, Smirnov I.7, Fedotov A.7
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Afiliações:
- Human Stem Cells Institute
- Moscow State University of Medicine and Dentistry
- State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Federal Research Center Crystallography and Photonics
- Ryazan State Medical University
- Kazan (Volga Region) Federal University
- Baikov Institute of Metallurgy and Materials Science
- Edição: Volume 9, Nº 1 (2018)
- Páginas: 70-74
- Seção: Article
- URL: https://journals.rcsi.science/2075-1133/article/view/207116
- DOI: https://doi.org/10.1134/S2075113318010045
- ID: 207116
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Resumo
This work is aimed at the optimization of the phase composition, surface morphology, and microstructure of matrices based on octacalcium phosphate (OCP) in order to increase the maximum dose and dosing accuracy of immobilized nucleic acids (NAs). It is determined that the modification of the scaffold with magnesium leads to a 1.4-fold increase in binding of plasmid DNA, which can further be used for the fabrication of medical products with the specified high concentration of biologically active NAs. Preliminary in vitro evaluation shows that the addition of magnesium to OCP regulates metabolic activity of HEK-293FT cell lines.
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Sobre autores
I. Bozo
Human Stem Cells Institute; Moscow State University of Medicine and Dentistry; State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal Research Center Crystallography and Photonics
Email: komlev@mail.ru
Rússia, Moscow; Moscow; Moscow; Moscow
R. Deev
Human Stem Cells Institute; Federal Research Center Crystallography and Photonics; Ryazan State Medical University
Email: komlev@mail.ru
Rússia, Moscow; Moscow; Ryazan
M. Zhuravlyova
Kazan (Volga Region) Federal University
Email: komlev@mail.ru
Rússia, Kazan
V. Komlev
Federal Research Center Crystallography and Photonics; Baikov Institute of Metallurgy and Materials Science
Autor responsável pela correspondência
Email: komlev@mail.ru
Rússia, Moscow; Moscow
V. Popov
Federal Research Center Crystallography and Photonics
Email: komlev@mail.ru
Rússia, Moscow
I. Smirnov
Baikov Institute of Metallurgy and Materials Science
Email: komlev@mail.ru
Rússia, Moscow
A. Fedotov
Baikov Institute of Metallurgy and Materials Science
Email: komlev@mail.ru
Rússia, Moscow