Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions


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Аннотация

This work is aimed at the optimization of the phase composition, surface morphology, and microstructure of matrices based on octacalcium phosphate (OCP) in order to increase the maximum dose and dosing accuracy of immobilized nucleic acids (NAs). It is determined that the modification of the scaffold with magnesium leads to a 1.4-fold increase in binding of plasmid DNA, which can further be used for the fabrication of medical products with the specified high concentration of biologically active NAs. Preliminary in vitro evaluation shows that the addition of magnesium to OCP regulates metabolic activity of HEK-293FT cell lines.

Авторлар туралы

I. Bozo

Human Stem Cells Institute; Moscow State University of Medicine and Dentistry; State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Federal Research Center Crystallography and Photonics

Email: komlev@mail.ru
Ресей, Moscow; Moscow; Moscow; Moscow

R. Deev

Human Stem Cells Institute; Federal Research Center Crystallography and Photonics; Ryazan State Medical University

Email: komlev@mail.ru
Ресей, Moscow; Moscow; Ryazan

M. Zhuravlyova

Kazan (Volga Region) Federal University

Email: komlev@mail.ru
Ресей, Kazan

V. Komlev

Federal Research Center Crystallography and Photonics; Baikov Institute of Metallurgy and Materials Science

Хат алмасуға жауапты Автор.
Email: komlev@mail.ru
Ресей, Moscow; Moscow

V. Popov

Federal Research Center Crystallography and Photonics

Email: komlev@mail.ru
Ресей, Moscow

I. Smirnov

Baikov Institute of Metallurgy and Materials Science

Email: komlev@mail.ru
Ресей, Moscow

A. Fedotov

Baikov Institute of Metallurgy and Materials Science

Email: komlev@mail.ru
Ресей, Moscow

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