Nefopam as a component of multimodal postoperative analgesia: the result in the group of patients undergone surgery for head and neck tumors in context of multicenter trial


Cite item

Full Text

Abstract

The goal of the study was to evaluate the affectivity of nefopam in postoperative pain management. Two hundred patients were enrolled into the prospective multicenter study on the base of 8 leading research centers of Russian Federation. The cohort includes 25 adult patients undergone surgery for head and neck tumors from Blokhin Russian Oncologic Research Center. All patient received analgesia for 3 postoperative days along the following scheme: nefopam 20mg i.v. 30 min before the end of the surgery, then every 8 hours combination of nefopam and NSAID. Visual- analogical 10-ball scale was used to evaluate analgesia. The results of the study suppose effectiveness and safety of nefopam as a component of postoperative multimodal analgesia.

About the authors

V. V Balandin

FSBI “N.N. Blokhin Russian Cancer Research Center” RAMS

115478, Moscow

Evgeniy S. Gorobets

FSBI “N.N. Blokhin Russian Cancer Research Center” RAMS

Email: egorobets@mail.ru
115478, Moscow

References

  1. Dolin S., Cashman J., Blad S. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br. J. Anaesth. 2002; 89: 409-423.
  2. Овечкин А.М., Свиридов С.В. Послеоперационная боль и обезболивание: современное состояние проблемы. Медицина критических состояний. 2011; 6(37): 20-31.
  3. Strom B., Berlin J., Kinman J. Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. JAMA. 1996; 275: 376-382.
  4. Huang N., Cunningham F., Laurito C. E. et al. Can we do better with postoperative pain management? Am J Surg. 2001 Nov; 182(5): 440-448.
  5. Kehlet H., Dahl J.B. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth. Analg. 1993; 77:1048-1056.
  6. Kehlet H. Labat Lecture 2005. Surgical stress and postoperative outcome - from here to where? Reg. Anesth. Pain Med. 2006; 31: 47-52.
  7. Fernandez-Sanchez М., Diaz-Trelles R., Groppetti A. Nefopam, an analogue of or-phenadrine, protects against both NMDA receptor-dependent and independent vera-tridine-induced neurotoxicity. Amino Acids. 2002; 23: 31-36.
  8. Verleye M., Andre N., Heulard I., Gillardin J. Nefopam blocks voltagesensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004; 1013: 249-255.
  9. Kapfer et al. Nefopam and ketamine comparably enhance postoperative analgesia. Anesth. Analg. 2005; 100: 169-174.
  10. Tirault et al. The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth. Analg. 2006; 102: 110-117.
  11. Bilotta F., Pietropaoli P., Sanita R. Nefopam and tramadol for the prevention of shivering during neuroaxial anesthesia. Reg. Anesth.Pain.Med. 2002; 27: 380-384
  12. Piper S., Suttner S., Schmidt S. Nefopam and clonidine in the prevention of postanesthetic shivering. Anaesthesia. 1999; 54: 695-699.
  13. Piper S., Rohm K., Suttner S. A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study. Anaesthesia. 2004; 59: 559-564.
  14. Delage N., Maaliki H., Beloeil H. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients. Anesthesiology. 2005; 102: 1211-1216.

Copyright (c) 2015 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies